Dataset Information

Analysis of plasma proteome of pregnant women with polycystic ovary syndrome (PCOS

ABSTRACT: Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder of fertile-aged women. PCOS has been associated with adverse pregnancy outcomes and abnormalities of the placenta. By taking a quantitative label-free quantitative proteomics approach we set out to investigate if changes in the plasma proteome of pregnant women with PCOS could elucidate the mechanisms behind the pathologies observed in PCOS pregnancies. We have performed label-free quantitative proteomics on plasma samples from pregnant women with PCOS at term (n=14) and plasma samples from pregnant control women (n = 23) matched for age, gestational length and BMI. The samples are derived from BASIC pregnancy cohort from Uppsala, Sweden. A total of 169 proteins with two or more unique peptides were identified.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Polycystic Ovary Syndrome

SUBMITTER: Sakari Joenväärä

LAB HEAD: Terhi T. Piltonen

PROVIDER: PXD012034 | Pride | 2019-11-25

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20180427_PCOS_PREGNANCY_PROTEOMICS_01.raw.zip	Raw
	20180427_PCOS_PREGNANCY_PROTEOMICS_02.raw.zip	Raw
	20180427_PCOS_PREGNANCY_PROTEOMICS_03.raw.zip	Raw
	20180427_PCOS_PREGNANCY_PROTEOMICS_04.raw.zip	Raw
	20180427_PCOS_PREGNANCY_PROTEOMICS_05.raw.zip	Raw

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Publications

Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics.

Arffman R K RK Saraswat M M Joenväärä S S Khatun M M Agarwal R R Tohmola T T Sundström-Poromaa I I Renkonen R R Piltonen T T TT

Scientific reports 20191126 1

Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder of fertile-aged women. Several adverse pregnancy outcomes and abnormalities of the placenta have been associated with PCOS. By using quantitative label-free proteomics we investigated whether changes in the plasma proteome of pregnant women with PCOS could elucidate the mechanisms behind the pathologies observed in PCOS pregnancies. A total of 169 proteins with ≥2 unique peptides were detected to be differentially expr ...[more]

PMID: 31772271

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