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Rapid nutritional regulation of oligodendrocytes of the adult hypothalamic median eminence revealed by single-cell transcriptomic analysis

ABSTRACT: Rapid nutritional regulation of oligodendrocytes of the adult hypothalamic median eminence revealed by single-cell transcriptomic analysis

PROVIDER: PRJNA552889 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9647170.fastq.gz	Fastqsanger.gz
	SRR9647180.fastq.gz	Fastqsanger.gz
	SRR9647190.fastq.gz	Fastqsanger.gz
	SRR9647171.fastq.gz	Fastqsanger.gz
	SRR9647181.fastq.gz	Fastqsanger.gz

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Rapid nutritional regulation of oligodendrocytes of the adult hypothalamic median eminence revealed by single-cell transcriptomic analysis

Project description:Rapid nutritional regulation of oligodendrocytes of the adult hypothalamic median eminence revealed by single-cell transcriptomic analysis

| PRJNA552889 | ENA

Rapid nutritional regulation of oligodendrocytes of the adult hypothalamic median eminence revealed by single-cell transcriptomic analysis

Project description:The median eminence (ME) of the hypothalamus is a structure that rapidly adapts to nutrient availability. We have used single-cell RNA sequencing to characterize the transcriptional profiles of cells specifically in the median eminence in the fasted and refed states. In our study, we focus on characterizing the oligodendrocyte population of the ME, and identifying how subpopulations respond to nutrient availability.

2021-06-30 | GSE133890 | GEO

Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging

Project description:Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging

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Adult Neurogenesis of the Median Eminence Contributes to Structural Reconstruction and Recovery of Body Fluid Metabolism in Hypothalamic Self-Repair

Project description:Purpose: To investigate the underlying regulatory mechanism of neurobiology induced by hypothalamic injury from basic gene expression profile, we extracted RNA from hypothalamic median eminence (ME) RNA sequencing (RNA-seq), at day 1 after control and PEL surgery. Results: We identified 811 differentially expressed genes (DEGs, defined as adjust p value < 0.05) between PEL_1d (day 1 after PEL) and control group. Conclusions:We revealed that RNA-seq based transcriptome characterization would expedite genetic network analyses of hypothalamic ME and permit the dissection of complex biologic functions during the process of central diabetes insipidus after PEL surgery.

2024-01-01 | GSE187602 | GEO

Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (DROP-seq)

Project description:Drop-Seq single cell RNA sequencing of hypothalamic arcuate nucleus and median eminence from wildtype and Irx3/5 double heterozygous mice

2021-02-18 | GSE142243 | GEO

Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

Project description:Single cell sequencing of Ins2-Cre;ptdTomato+ FACS sorted cells from micro-dissected hypothalamic arcuate nucleus and median eminence of wildtype and Irx3/5 double heterozygous mice.

2021-02-18 | GSE154969 | GEO

Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging

Project description:Aging is a slow and progressive natural process that compromises the normal functions of cells, tissues, organs and systems. The aging of the hypothalamic median eminence (ME), a structural gate linking neural and endocrine systems, may impair hormone release, energy homeostasis and central sensing of circulating molecules, leading to systemic and reproductive aging. However, the molecular and cellular features of ME aging remain largely unknown. Here we describe the transcriptional landscape of young and middle-aged mouse ME at single-cell resolution, revealing the common and cell-type-specific transcriptional changes with age. The transcriptional changes in cell-intrinsic programs, cell-cell crosstalk and cell-extrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular, signaling and molecular levels. Importantly, our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome. Together, our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process, which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.

2022-02-03 | GSE179442 | GEO

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

Project description:Drop-seq and single cell sequencing of mouse arcuate nucleus and median eminence

2017-02-06 | GSE90806 | GEO

Adult Neurogenesis of the Median Eminence Contributes to Structural Reconstruction and Recovery of Body Fluid Metabolism in Hypothalamic Self-Repair

Project description:Adult Neurogenesis of the Median Eminence Contributes to Structural Reconstruction and Recovery of Body Fluid Metabolism in Hypothalamic Self-Repair

| PRJNA777613 | ENA

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

Project description:Drop-seq and single cell sequencing of mouse arcuate nucleus and median eminence. Please see below link for searchable cluster-based gene expression.

2017-01-31 | GSE93374 | GEO

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