Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Carcharodon carcharias (Great white shark) genome, sCarCar2

PROVIDER: PRJNA562191 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	JAGDEE01.dat.gz	Other
	JAGDEE01.fasta.gz	Fasta.gz
	JAGDEE01.master.dat	Other
	JAGDEF01.dat.gz	Other

Items per page:

1 - 5 of 47

Similar Datasets

Carcharodon carcharias isolate:sCarCar2

Project description:Carcharodon carcharias (Great white shark) genome, sCarCar2, primary haplotype

| PRJNA562007 | ENA

Carcharodon carcharias isolate:sCarCar2

Project description:Carcharodon carcharias (Great white shark) genome, sCarCar2, alternate haplotype

| PRJNA562008 | ENA

Carcharodon carcharias

Project description:Carcharodon carcharias overview

| PRJNA223173 | ENA

Carcharodon carcharias

Project description:Carcharodon carcharias Transcriptome or Gene expression

| PRJNA177971 | ENA

Carcharodon carcharias

Project description:Carcharodon carcharias Transcriptome or Gene expression

| PRJNA485795 | ENA

The methylome of a cartilaginous fish, Callorhinchus milii, reveals conservation of epigenetic regulation across jawed vertebrates

Project description:Background Methylation of CG dinucleotides constitutes a critical system of epigenetic memory in bony vertebrates, where it modulates gene expression and suppresses transposon activity. The genomes of studied vertebrates are pervasively hypermethylated, with the exception of regulatory elements such as transcription start sites (TSSs), where the presence of methylation is associated with gene silencing. This system is not found in the sparsely methylated genomes of invertebrates, and establishing how it arose during early vertebrate evolution is impeded by a paucity of epigenetic data from basal vertebrates. Methods We perform whole-genome bisulfite sequencing to generate the first genome-wide methylation profiles of a cartilaginous fish, the elephant shark Callorhinchus milii. Employing these to determine the elephant shark methylome structure and its relationship with expression, we compare this with higher vertebrates and an invertebrate chordate using published methylation and transcriptome data. Results Like higher vertebrates, the majority of elephant shark CG sites are highly methylated, and methylation is abundant across the genome rather than patterned in the mosaic configuration of invertebrates. This global hypermethylation includes transposable elements and the bodies of genes at all expression levels. Significantly, we document an inverse relationship between TSS methylation and expression in the elephant shark, supporting the presence of the repressive regulatory architecture shared by higher vertebrates. Conclusions Our demonstration that methylation patterns in a cartilaginous fish are characteristic of higher vertebrates imply the conservation of this epigenetic modification system across jawed vertebrates separated by 465 million years of evolution. In addition, these findings position the elephant shark as a valuable model to explore the evolutionary history and function of vertebrate methylation.

2017-03-24 | GSE96683 | GEO

Carcharodon

Project description:Carcharodon spp. Genomic Resources

| PRJNA766284 | ENA

Elasmobranchii

Project description:Elasmobranch shark genome evolution

| PRJDB6260 | ENA

Shark Cartilage in Treating Patients With Advanced Colorectal or Breast Cancer

Project description:RATIONALE: Shark cartilage extract may help shrink or slow the growth of colorectal cancer or breast cancer cells. PURPOSE: Randomized phase III trial to determine the effectiveness of shark cartilage in treating patients who have advanced colorectal cancer or advanced breast cancer.

| 2006841 | ecrin-mdr-crc

Project description:Shark genome sequencing with MinION

| PRJNA503780 | ENA