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The role of Vitamin C and TET dioxygenases in genome-wide features of regulatory T cells

ABSTRACT: The role of Vitamin C and TET dioxygenases in genome-wide features of regulatory T cells

PROVIDER: PRJNA592355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10555400_1.fastq.gz	Fastqsanger.gz
	SRR10555400_2.fastq.gz	Fastqsanger.gz
	SRR10555500_1.fastq.gz	Fastqsanger.gz
	SRR10555500_2.fastq.gz	Fastqsanger.gz
	SRR10555600_1.fastq.gz	Fastqsanger.gz

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The role of Vitamin C and TET dioxygenases in genome-wide features of regulatory T cells [WGBS]

Project description:TET enzymes are essential for the stability and function of regulatory T cells (Tregs), which maintain immune homeostasis and self-tolerance and express the lineage-determining transcription factor Foxp3. We previously showed that Vitamin C acts through TET enzymes to maintain the demethylated status of CNS2, a key intronic enhancer of the Foxp3 gene that is essential for the stability of Foxp3 expression both in vivo and in vitro. Here we show that Vitamin C enables genome-wide features of “induced” T regulatory cells (iTregs) in vitro that overlap with those induced by TET proteins during Treg differentiation in vivo. Vitamin C enhances IL-2 responsiveness in iTregs by increasing phospho-STAT5 levels, STAT5 occupancy and DNA demethylation at key Treg-specific enhancers, and maintains the stable expression of Treg-specific genes including Foxp3 and Il2ra. Our data will be relevant to future studies of the association between plasma Vitamin C levels, Treg function and autoimmunity in humans.

2021-07-21 | GSE141151 | GEO