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Lymphoma transcriptome analysis after X-ray or Proton beam irradiation

ABSTRACT: Lymphoma transcriptome analysis after X-ray or Proton beam irradiation

PROVIDER: PRJNA600938 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10877913_1.fastq.gz	Fastqsanger.gz
	SRR10877913_2.fastq.gz	Fastqsanger.gz
	SRR10877914_1.fastq.gz	Fastqsanger.gz
	SRR10877914_2.fastq.gz	Fastqsanger.gz
	SRR10877916_1.fastq.gz	Fastqsanger.gz

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Lymphoma transcriptome analysis after X-ray or Proton beam irradiation

Project description:Proton (PT) therapy represents an alternative to conventional X-ray therapy, and its clinical application for cancer treatment is on the rise due to associated dose deposit advantages. However, our knowledge of biological responses to PT, in comparison to X-ray, remains in its infancy. Identification of PT specific molecular signals is an important opportunity for the discovery of biomarkers and synergistic drugs. We have profiled the transcriptome regulation of lymphoma cells exposed to clinical sources of PT and X-ray radiation, respectively. Subsequent analysis demonstrated both common and radiation-specific deregulation of gene expression. Gene set enrichment discovered pathways unique to PT \ that contribute to the unfolded protein response (UPR) and mitochondrial transport.

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Project description:The aim of the study is to disclose the distinct alteration of biological characteristics of gene expression features in pancreas cancer cell, MIAPaCa-2, irradiated by proton and x-ray. The survived MIAPaCa-2 cells after irradiation with proton and x-ray were isolated and gene expression profiles were analyzed.

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Biological characteristics of gene expression features in pancreatic cancer cell induced by proton and x-ray irradiation III

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Biological characteristics of gene expression features in pancreatic cancer cell induced by proton and x-ray irradiation I

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Radiation-Induced T Cell Lymphoma: Carbon ion- vs. Gamma Ray-Induced

Project description:Here, male and female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at the Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour volume. These mice were then monitored for the remainder of their lifespan and a large number of T cell lymphomas were analysed, alongside those arising in mice exposed to equivalent doses of standard Cs137 gamma ray-irradiation. Using genome-wide DNA copy number analysis to identify genomic loci involved in radiation-induced lymphomagenesis and subsequent detailed analysis of Notch1, Ikaros, Pten, Trp53 and Bcl11b genes we compared the genetic profile of the carbon ion- and gamma ray-induced tumours. The canonical set of genes previously associated with radiation-induced T cell lymphoma was identified in both radiation groups. While the pattern of disruption of the various pathways was somewhat different between the radiation types, most notably Pten mutation frequency and loss of heterozygosity flanking Bcl11b, the most striking finding was the observation of large interstitial deletions at various sites across the genome in carbon ion-induced tumours, which were only seen infrequently in the gamma ray-induced tumours analysed. 32 unique tumours (12 gamma ray-induced, 20 carbon ion-induced) each with sex-matched reference DNA

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microarray of healthy heart tissue of mouse (BALB/c nude female mice) after proton-beam treatment to cure breast cancer

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