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Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (mRNA-seq dataset)

ABSTRACT: Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (mRNA-seq dataset)

PROVIDER: PRJNA604010 | ENA |

REPOSITORIES: ENA

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Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (mRNA-seq dataset)

Project description:The goals of the study are to compare differently expressed genes in heart tissues of hypertensive rats (spontaneously Hypertension Rats, SHR) with age-matched control rats (wistar Rats, WKY), identify new targets to reverse hypertension induced cardiac remodeling and idetify the targets of Traditional Chinese Medicine QDG.

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Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling (miRNA-seq dataset)

Project description:The goals of the study are to compare differently expressed genes in heart tissues of hypertensive rats (spoutaneously Hypertension Rats, SHR) with age-matched control rats (wistar Rats, WKY), identify new targets to reverse hypertension induced cardiac remodeling and idetify the targets of Traditional Chinese Medicine QDG.

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Integrated analysis of miRNA-mRNA interactions reveals novel target pathways in hypertension-induced cardiac remodeling

Project description:This SuperSeries is composed of the SubSeries listed below.

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Integrated analysis of proteomics on rat hearts with aging and hypertension

Project description:Hypertension is a most important risk factor of cardiovascular diseases (CVD), and its incidence is greatest among older adults, which indicates that aging is an independent risk for both hypertension and CVD. To date, the studies on the proteomics and phosphoproteomics of the aged hypertensive hearts for studying their impacts on the pathogenesis of CVD are limited. Here we present a dataset by using proteomics and phosphor-proteomics analysis on young and aged healthy and spontaneous hypertensive (SHR) rats. The dataset has following features: 1) numerical description of average 4000 total proteins and 1500 phosphor-proteins of detectable proteins in each group; 2) proteomic and phosphoproteomic profiles of their expression patterns; 3) Pathways for individual factor (age or hypertension) and their interaction and association with CVDs. Therefore, the integrated analysis of the dataset revealed the underlying pathways of aging and/or hypertension and their interaction on cardiovascular remodelling. In summary, the dataset provides a searchable multi-omics for the researchers to explore the interaction of aging and hypertension on the pathogenesis of CVD.

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