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Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model (RNA-Seq)

ABSTRACT: Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model (RNA-Seq)

PROVIDER: PRJNA608711 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11179785_1.fastq.gz	Fastqsanger.gz
	SRR11179785_2.fastq.gz	Fastqsanger.gz
	SRR11179786_1.fastq.gz	Fastqsanger.gz
	SRR11179786_2.fastq.gz	Fastqsanger.gz
	SRR11179787_1.fastq.gz	Fastqsanger.gz

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Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model

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Project description:The assay for transposase-accessible chromatin by sequencing (ATAC-seq) was used to investigate the AD-associated chromatin reshaping in the APPswe/PS1dE9 (APP/PS1) mouse model. ATAC-seq data in the hippocampus of 8-month-old APP/PS1 mice were generated, and the relationship between chromatin accessibility and gene expression was analyzed in combination with RNA-sequencing.We identified 1690 increased AD-associated chromatin accessible regions in the hippocampal tissues of APP/PS1 mice and 1003 decreased chromatin accessible regions were considered to be related with declined AD-associated biological processes.In the APP/PS1 hippocampus, 1090 genes were found to be up-regulated and 1081 down-regulated. Interestingly, enhanced ATAC-seq signal was found in approximately 740 genes, with 43 exhibiting up-regulated mRNA levels.Our study reveals that alterations in chromatin accessibility may be an initial mechanism in AD pathogenesis.

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