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Differentially RNA expressions of brain metastases from lung adenocarcinoma and paired paracancerous tissue

ABSTRACT: Differentially RNA expressions of brain metastases from lung adenocarcinoma and paired paracancerous tissue

PROVIDER: PRJNA610615 | ENA |

REPOSITORIES: ENA

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Differentially RNA expressions of brain metastases from lung adenocarcinoma and paired paracancerous tissue

Project description:This study aims to find the specific lncRNA molecule relating BMs from LADC in situ tumor to BM tumor tissue using gene chip technology and, combined with biological information database, through the competitive endogenous RNA (ceRNA) mechanism for microRNA (miRNA) related to specific lncRNA, to verify the possible target genes and therefore to explore the role and mechanism of specific lncRNA in BMs from LADC. By detecting the gene expression profiles of lncRNA and mRNA in cancer tissues of five cases of LADC and the paired paracancerous tissue samples, it was found that there were a large number of differentially expressed lncRNAs and mRNAs in LADC tissues and paracancerous tissues. By detecting the gene expression profiles of lncRNA and mRNA in three cases of BMs from LADC and matched paracancerous tissues, it was found that there were significant differences in the expression of lncRNAs and mRNAs between BM tumors of LADC and paracancerous tissues. These findings will provide a scientific basis for the early diagnosis and targeted therapy of BMs from LADC for application in further studies. Differential expression of lncRNAs and mRNAs in cancer tissues of three cases of BMs from LADC and the paired paracancerous tissue samples, it was found that there were a large number of differentially expressed lncRNAs and mRNAs in BMs tissues and paracancerous tissues.

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Differentially RNA expression of lung adenocarcinoma and paired paracancerous tissue

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Differentially RNA expression of lung adenocarcinoma and paired paracancerous tissue

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