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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

ABSTRACT: Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

PROVIDER: PRJNA614484 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11392110.fastq.gz	Fastqsanger.gz
	SRR11392111.fastq.gz	Fastqsanger.gz
	SRR11392112.fastq.gz	Fastqsanger.gz
	SRR11392113.fastq.gz	Fastqsanger.gz
	SRR11392114.fastq.gz	Fastqsanger.gz

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of memory and effector T cells. Here, we used a series of high-dimensional approaches guided by single-cell RNA sequencing data to map the organizational structure of the human CD8+ memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically, and transcriptionally distinct stem-like CD8+ memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data revealed the existence of parallel differentiation programs in the human CD8+ memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

2020-08-03 | GSE147394 | GEO

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

2020-08-03 | GSE147397 | GEO

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

2020-08-03 | GSE147395 | GEO

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-03 | GSE147398 | GEO

CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

Project description:CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

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CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

Project description:Through gene expression analysis of CMPs and GMPs at single cell levels, we identified CD62L as a marker to reveal the heterogeneity of CMPs and GMPs. We confirmed that the CD62L-low CMPs represent ‘bona fide’ CMPs, whereas CD62L-high CMPs are mostly restricted to GMP potentials both in mice and humans. In addition, we identified CD62L-neg GMPs as the most immature subsets in GMPs and Ly6c+CD62L-low and Ly6c+CD62L-high GMPs are skewed to neutrophil and monocyte differentiation, respectively. We performed gene expression profiling of CD62L-low CMPs, CD62L-high CMPs, CD62L-neg GMPs, CD62L-low GMPs, CD62L-high GMPs, bulk CMPs, and bulk GMPs.

2021-02-04 | GSE166065 | GEO

A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs versus humans

Project description:A network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner’s Glands (BGs) in the submucosa of the duodenum, in peribiliary glands (PBGs) of intrahepatic and extrahepatic biliary trees, and in pancreatic duct glands (PDGs) of intrapancreatic biliary trees, collectively supporting hepatic and pancreatic regeneration postnatally. The network is found in humans postnatally throughout life and, so far, has been demonstrated in pigs postnatally at least through to young adults. These stem/progenitors in vivo in pigs are in highest numbers in BGs and in PDGS nearest the duodenum, and in humans are in BGs and in PBGs in the hepato/pancreatic common duct, a duct missing postnatally in pigs. Elsewhere in PDGs in pigs and in all PDGs in humans are only committed unipotent or bipotent progenitors.

2023-08-02 | GSE229270 | GEO

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