Project description:Our study is designed to demonstrate altered profiles of circRNAs in the luteal-phase endometrium from patients with RIF. Functional studies will be further confirmed. This study will provide new viewpoint for understanding the roles of non-coding RNA for endometrial stromal cells and epithelial cells function, as well as potential etiologic mechanism for RIF.
Project description:Patient-control group project investigating recurrent failure of embryo-implantation by expression analysis of endometrium biopsies
Project description:To evaluate differentially expressed circRNAs in patients with recurrent implantation failure, we used circRNA microarrays to screen circRNA expression profiles in endometrial biopsies from 6 women with recurrent implantation failure and controls. Our study revealed for the first time a unique set of circRNA expression signatures in the endometrial tissue of patients with repeated implantation failure, which may provide new molecular candidates for the diagnosis and clinical treatment of embryo implantation failure.
Project description:A microarray study about miRNA expression profiles in recurrent implantation failure patients as compare with who had got pregnancy after embryo implantation no more than three times To detect the miRNAs that may regulate endometrial receptivity by microarray study
Project description:Recurrent implantation failure (RIF) is a challenge in the field of reproductive medicine. The dysfunction of endometrium is one of the pathogenesis of implantation failure. We used microarrays to detail the global programme of gene expression underlying the molecular pathogenesis of implantation failure.
Project description:To compare the lncRNA expression profile of RIF (recurrent implantation failure) and normal control endometrium,endometrium samples were collected at window of implantation (LH+6~10 days) The dysregulated lncRNAs between RIF and control group were deem to be involve in the regulation of endometrium receptivity
Project description:We aimed to identify altered biological processes in the endometrium that may be potential markers of receptive endometrium. RNA expression profiling of the endometrium during the window of implantation was performed in patients with Recurrent Implantation Failure (RIF) versus fertile controls.
Project description:we utilized Exiqon miRCURY™ LNA Array (v18.0, Exiqon, Vedbaek, Denmark) to establish miRNA expression profiles in the endometrial tissues at the time of embryo implantation(day 7 after ovulation) from 8 RIF patients and 10 matched controls. A total of 157 miRNAs exhibited distinct expression patterns in RIF patients as opposed to controls (fold change >2.0 and P-value <0.05).
Project description:Patient-control group project investigating recurrent failure of embryo-implantation by expression analysis of endometrium biopsies