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Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

ABSTRACT: Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

PROVIDER: PRJNA622525 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11465449_1.fastq.gz	Fastqsanger.gz
	SRR11465449_2.fastq.gz	Fastqsanger.gz
	SRR11465450_1.fastq.gz	Fastqsanger.gz
	SRR11465450_2.fastq.gz	Fastqsanger.gz
	SRR11465451_1.fastq.gz	Fastqsanger.gz

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Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Project description:Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

| PRJNA622522 | ENA

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

Project description:Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

| PRJNA622526 | ENA

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses.

Project description:CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term protective immunity. Despite their critical roles, the precise mechanics governing TRM cell reactivation in situ are unknown. Using a TCR-transgenic Nur77-GFP reporter to distinguish "antigen-specific" from "bystander" reactivation, we demonstrate that lung CD8+ TRM cells are reactivated more quickly, yet less efficiently, than their counterparts in the draining LNs (TLN cells). Global profiling of reactivated memory T cells revealed tissue-defined and temporally regulated recall response programs. Unlike the reactivation of CD8+ TLN cells, which is strictly dependent on CD11c+XCR1+ APCs, numerous antigen-presenting partners, both hematopoietic and non-hematopoietic, were sufficient to reactivate lung CD8+ TRM cells, but the quality of TRM cell functional responses depended on the identity of the APCs. Together, this work uncovers fundamental differences in the activation kinetics, mechanics, and effector responses between CD8+ memory T cells in peripheral vs. lymphoid organs, revealing a novel tissue-specific paradigm for the reactivation of memory CD8+ T cells.

| S-EPMC7398161 | biostudies-literature

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-02 | GSE147908 | GEO

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [II]

Project description:Temporal transcriptome profiling of TCR-reactivated (P14) and bystander-reactivated (OT-I) memory T cells in the lung and mediastinal lymph node based on Nur77-GFP reporter expression and CD98 expression

2020-04-02 | GSE147907 | GEO

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [I]

Project description:Global profiling to investigate the consequence of the lack of TAP-1 on hematopoetic cell or non-hematopoetic cell on the qualitative response of reactivated antigen-specific Trm cells

2020-04-02 | GSE147906 | GEO

Antigen Presenting Dendritic Cells

Project description:Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

2004-09-30 | GSE702 | GEO

Antigen presenting cells of myeloid origin

Project description:Transcriptional profiles of four different myeloid antigen presenting cell (APC) subsets (BDCA-1+ circulating myeloid dendritic cells, CD14+ monocytes, and in vitro generated immature and mature monocyte-derived dendritic cells) were used for comprehensive transcriptome analysis. Based on the gene expression profiling data, a quantitative relationship between myeloid APC in functionally related gene spaces was established. Keywords = myeloid antigen presenting cells Keywords = dendritic cell subsets Keywords: repeat sample

2017-12-21 | GSE2215 | GEO

Assessment of genome-wide chromatin accessibility of subsets of bone marrow-resident antigen presenting cells [ATAC_BMACs]

Project description:Chromatin accessibility of bone marrow-resident Aire expressing cells was compared to those of bone marrow plasma cells and B cells via ATAC-seq Bone marrow (BM) harbors a large repertoire of regulatory T (Treg) cells, which are essential in hematopoiesis and peripheral tolerance. Treg cell accumulation in BM has been viewed as a consequence of preferential immigration of thymus-derived Treg cells. Here we report a novel subset of antigen presenting cells, which expresses the autoimmune regulator (Aire). These BM Aire-expressing cells resemble a subset of CD138+B220-TACI+Blimp-1+MHC-II+ plasma cells (pc-BMACs) and express a diverse repertoire of tissue-restricted self-antigens. pc-BMACs present self-antigens to na ve CD4+ T cells and can efficiently convert these into functionally competent CD25+Foxp3+ bona fide peripheral Treg cells (pTregs) capable of exerting immune suppression in vitro and in vivo. Aire expression may contribute to the tolerogenic function of pc-BMACs as it regulates the expression of genes involved in pTreg induction and function, including Icosl and retinoic acid synthesis-related genes, Aldh1a2 and Aldh1b1. Our data thus demonstrate an Aire-expressing plasma cell subset in the BM capable to promote peripheral tolerance by ectopically expressing tissue-restricted self-antigens and generating pTregs.

2022-08-26 | GSE136649 | GEO

Delineating Tumor-infiltrating Antigen Presenting Cell populations

Project description:The goal of this study is to compare tumor-infiltrating antigen presenting cell populations by global transcriptome profiling (RNA-seq) to help further delineate sub-populations of infiltrating myeloid cells in tumor. Methods: Four tumor antigen presenting cell populations were sorted from digested B78chOVA (melanoma variant) tumors in biological triplicate Results: RNA was extracted from the 4 groups (n=3 per group) and prepared for RNAseq. Sequencing yielded ~405 million reads with an average read depth of 33.7 million reads/sample. Reads were then aligned to the mouse genome (UCSC mm10) and those that mapped uniquely to known mRNAs were used to assess differential expression.

2014-11-10 | GSE61462 | GEO

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