Ontology highlight
ABSTRACT:
PROVIDER: PRJNA626342 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Boreal toads (Anaxyrus boreas boreas) of the Southern Rocky Mountain population are declining due to the introduction of the chytrid fungus Batrachochytrium dendrobatidis (Bd). Boreal toads in Colorado are generally susceptible to Bd infection, but some Bd-tolerant populations persist in parts of the Southern Rocky Mountain and broader Eastern boreal toad population. We conducted a Bd challenge with lab-reared sibling toads from Bd-susceptible Colorado and purportedly Bd-tolerant Utah populations and report on transcriptomic responses to Bd during late infection in skin and liver tissue. Fewer immune genes were expressed in response to Bd in Colorado toads, but with greater upregulation compared to Utah toads, indicating a dysregulated immune response. Signatures of Bd-tolerance in Utah toads included more moderate upregulation in immune gene expression and a significantly enriched suite of gene functions related to innate and adaptive immune responses. Our transcriptomic results support the notion that Utah toads are tolerant to Bd, rather than resistant, carrying Bd loads similar to Colorado yet having a unique transcriptomic profile and presenting minimal clinical signs of chytridiomycosis. We conclude that closely related populations have divergent transcriptomic responses to Bd with a dysregulated immune response in Bd-susceptible toads.
2023-10-04 | GSE244617 | GEO
Project description:This SuperSeries is composed of the following subset Series: GSE23054: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v1 array) GSE23364: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v2 array) Refer to individual Series
2010-08-04 | E-GEOD-23377 | biostudies-arrayexpress
Project description:This series represents the 16 arrays that were used to identify expression differences between the alternative morphs of Spadefoot toads (Spea bombifrons). We used Affymetrix GeneChip Xenopus tropicalis genome arrays, 8 biological replicates for two ecotypes (morphs).
2011-12-31 | E-MEXP-3324 | biostudies-arrayexpress
Project description:Barcoding of Chrysomelidae of Euro-Mediterranean area: efficiency and problematic species
| PRJEB27360 | ENA
Project description:Mitonuclear communication is essential to maintain cellular and organismal homeostasis in equilibrium and stress. Mitochondrial stress activates a concerted mitonuclear response geared to safeguard and repair mitochondrial function and to adapt cellular metabolism to the stress. However, the common mediator driving this stress response in mammals remains elusive. By using a multi-omics approach we identify that the activating transcription factor 4 (ATF4) is the main player regulating this response. ATF4 activates the expression of cytoprotective genes, which reprogram cellular metabolism, through activation of the integrated stress response (ISR). Mitochondrial stress also promotes a local proteostatic response, by inducing a decrease in mitochondrial ribosomal proteins, inhibiting mitochondrial translation and coupling as such the activation of the ISR with the attenuation of mitochondrial function. Our data illustrate the value of a multi-omics approach to characterize complex cellular networks and provide a versatile resource to identify new regulators of mitochondrial-related diseases.
2017-06-01 | PXD006293 | Pride
Project description:LC-MS/MS data used in a work titled "Assessing Specialized Metabolite Diversity of Alnus species by Digitized LC_MS/MS Data Analysis Workflow". Negative ion mode DDA data from 15 extracts of 4 Alnus species (barks, twigs, leaves, and fruits)
2019-08-12 | MSV000084202 | MassIVE