Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

ABSTRACT: Overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

PROVIDER: PRJNA629117 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11638445_1.fastq.gz	Fastqsanger.gz
	SRR11638445_2.fastq.gz	Fastqsanger.gz
	SRR11638446_1.fastq.gz	Fastqsanger.gz
	SRR11638446_2.fastq.gz	Fastqsanger.gz
	SRR11638447_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Transcriptome analysis of overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

Project description:Transcriptome analysis of overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

| PRJNA629121 | ENA

Transcriptome analysis of overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

Project description:The goal of this study is to compare NGS-derived transcriptome profiling (RNA-seq) of alpha-synuclein expressing Sh-SY5Y cells vs. lacZ control protein and find characteristic changes that may be related to alpha-synucleinopathies. Our results showed the enrichments of p53 pathways, DNA damage responses, and cellular senescence. Further studies validated genes involved in such pathways.

2022-03-09 | GSE149559 | GEO

Overexpressed SNCA in differentiated SH-SY5Y neuroblastoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-09 | GSE149560 | GEO

3P-seq analysis of APP, BACE1, MAPT, and SNCA mRNAs in undifferentiated SH-SY5Ycells

Project description:To determine expressed 3' end isoforms for APP, BACE1, MAPT, and SNCA mRNAs in undifferentiated SH-SY5Y cells

2024-10-24 | GSE231101 | GEO

Profiling neuroblastoma SH-SY5Y with Paraquat treatment

Project description:Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared with respect to Human SH-SY5Y neuroblastoma cells treated with Paraquat. Parqaut treatment was done as described by Maracchioni, A., Totaro, A., Angelini, D.F., Di Penta, A., Bernardi, G., Carri, M.T., and Achsel, T. (2007) J Neurochem 100, 142-153

2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress

H3K27me3 ChIP-seq in SH-SY5Y human neuroblastoma cell line

Project description:H3K27me3 ChIP-seq was performed on: 1) untreated SH-SY5Y human neuroblastoma cells (day 0) 2) vincristine-treated SH-SY5Y human neuroblastoma cells (7 days of treatment - day 7) 3) vincristine-treated SH-SY5Y human neuroblastoma cells (7 days of treatment + 7 days of recover - day 14)

2022-10-01 | E-MTAB-11219 | biostudies-arrayexpress

Gene expression profile during SH-SY5Y neuroblastoma differentiation

Project description:Neuroblastoma cells SH-SY5Y undergoes a morphology change upon retinoic acid (RA) treatment, the neurite outgrowth characteristic in undividing cells is accompanied by cell cycle arrest and neuronal markers expression, controlled by a precise dynamic molecular circuits. Depletion of CSB in SH-SY5Y cells leads to differentiation defects. This study examines the temporal gene expression profile during differentiation. Using Nimblegen microarray we characterized the gene expression profiles before and after RA treatment in both wild type and CSB-KD SH-SY5Y cells, and we identified the difference in gene expression between wild type and CSB-KD cells underlying the differentiation defects induced by CSB depletion.

2014-09-22 | GSE58070 | GEO

Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71

Project description:Non-structural 2B protein of enterovirus-A71 has reported involving in intracellular Ca2+ manipulation and altering cellular homeostasis such as inducing cell death in human SH-SY5Y cells. The aim of the study is to profile transcriptomic signature of human neuroblastoma SH-SY5Y cells altered by EV-A71 2B protein using RNA-sequencing analysis. We generated mRNA expression profiles of SH-SY5Y cells transfected with EV-A71 2B protein fused with mCherry and FLAG tag protein (2BmCherry) and mCherry as well as parental SH-SY5Y cells. We find that 7 genes including CCL2, RELB, IL32, PLAT, PTGES, PHLDA1, and TNFRSF9 are uniquely overexpressed in 2BmCherry comparing to mCherry. Moreover, there were 333 upregulated and 333 downregulated genes showed significant different expression level in 2BmCherry transcriptome in comparison with SHSY5Y transcriptome but not in mCherry vs SHSY5Y comparison. Functional analysis showed that EV-A71 2B upregulated genes involved Ca2+-related signaling pathways participating gene expression, immune response, apoptosis, and long-term potentiation (synaptic adaptation) of neuron in the transfected SH-SY5Y cells.

2021-12-23 | GSE191270 | GEO

Whole Genome Bisulfite Sequencing (WGBS) of the SH-SY5Y human neuroblastoma cell line

Project description:WGBS was performed on: 1) untreated SH-SY5Y human neuroblastoma cells (day 0) 2) vincristine-treated SH-SY5Y human neuroblastoma cells (7 days of treatment - day 7) 3) vincristine-treated SH-SY5Y human neuroblastoma cells (7 days of treatment followed by 7 days of recovery - day 14)

2022-10-01 | E-MTAB-11223 | biostudies-arrayexpress

Profiling neuroblastoma SH-SY5Y with Paraquat treatment

2010-12-22 | GSE21305 | GEO