Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma

ABSTRACT: Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma

PROVIDER: PRJNA630901 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11727500.fastq.gz	Fastqsanger.gz
	SRR11727501.fastq.gz	Fastqsanger.gz
	SRR11727502.fastq.gz	Fastqsanger.gz
	SRR11727503.fastq.gz	Fastqsanger.gz
	SRR11727504.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 73

Similar Datasets

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (ATAC-Seq Neutrophils)

Project description:Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (ATAC-Seq Neutrophils)

| PRJNA630897 | ENA

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils)

Project description:Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils)

| PRJNA630915 | ENA

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils TGFbeta)

Project description:Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils TGFbeta)

| PRJNA630912 | ENA

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Epigenetic treatments)

Project description:Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Epigenetic treatments)

| PRJNA630913 | ENA

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils)

Project description:Purpose: we aimed at providing the phenotypic profile of G-MDSCs based on their prognostic significance in MM, immunosuppressive potential, and molecular program. Methods and results: The pre-established phenotype of G-MDSCs was evaluated in bone marrow samples from controls and MM patients using multidimensional flow cytometry and, surprisingly, we found that CD11b+CD14-CD15+CD33+HLADR- cells overlapped with common eosinophils and neutrophils, which were not expanded in MM patients. Thus, we relied on automated clustering to unbiasedly identify all granulocytic subsets in the tumor microenvironment: basophils, eosinophils, immature, intermediate and mature neutrophils. In a series of 267 newly-diagnosed MM patients (GEM2012MENOS65 trial), only the frequency of mature neutrophils at diagnosis was significantly associated with patients’ outcome, and a high mature-neutrophils/T-cell ratio resulted in inferior progression-free survival (P<.001). Upon FACSorting of each neutrophil subset, T cell proliferation decreased in presence of mature neutrophils (0.5-fold; P=.016) and the cytotoxic potential of T cells engaged by a BCMAxCD3 bispecific antibody increased notably with the depletion of mature neutrophils (4-fold; P=.0007). Most interestingly, RNAseq of the three subsets revealed that G-MDSCs-related genes were specifically upregulated in mature neutrophils from MM patients vs controls due to differential chromatin accessibility. Conclusion: Taken together, we established a correlation between the clinical significance, immunosuppressive potential and transcriptional network of well-defined neutrophil subsets, providing for the first time, a set of optimal markers (CD11b/CD13/CD16) for accurate monitoring of G-MDCSs in MM.

2020-05-08 | GSE150021 | GEO

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (ATAC-Seq Neutrophils)

2020-05-08 | GSE150018 | GEO

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Epigenetic treatments)

2020-05-08 | GSE150020 | GEO

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma (RNA-Seq Neutrophils TGFbeta)

2020-05-08 | GSE150019 | GEO

Immunogenomic identification and characterization of granulocytic myeloid derived suppressor cells in multiple myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-08 | GSE150023 | GEO

RNA-seq of human multiple myeloma patients myeloid-derived suppressor cells (M-MDSC)

Project description:The aim of this study is to evaluate prognostic impact of M-MDSCs (Myeloid-derived suppressor cells) in multiple myeloma (MM) remains in the context to autologous stem cell transplantation (ASCT).

2020-11-26 | E-MTAB-9767 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data