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Metabolic programming drives proximal tubule differentiation and kidney dysfunction

ABSTRACT: Metabolic programming drives proximal tubule differentiation and kidney dysfunction

PROVIDER: PRJNA640369 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12045487_1.fastq.gz	Fastqsanger.gz
	SRR12045487_2.fastq.gz	Fastqsanger.gz
	SRR12045488_1.fastq.gz	Fastqsanger.gz
	SRR12045488_2.fastq.gz	Fastqsanger.gz
	SRR12045489_1.fastq.gz	Fastqsanger.gz

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Effect of GW4064 on primary cultured mouse kidney proximal tubule cells

Project description:Global gene expression in the primary cultured mouse kidney proximal tubule cells treated either DMSO or 1uM GW4064 (a FXR agonist) was compared. Results provide insight into mechanisms underlying effects of FXR activation on gene expression in mouse kidney proximal tubule cells. Male C57/BJ mice aged 6 weeks were sacrificed under anesthesia and kidney proximal tubule cells were cultured until confluent. Cells were treated with either GW4064 (1uM) or equal amount of DMSO and incubated for 24 hours. 4 total RNA samples per group were analyzed and gene expression was compared between the groups.

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Metabolic programming drives proximal tubule differentiation and kidney dysfunction

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