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Aflatoxin B1 attenuates endocrine function, protein synthesis and energy production of human primary trophoblast

ABSTRACT: Aflatoxin B1 attenuates endocrine function, protein synthesis and energy production of human primary trophoblast

PROVIDER: PRJNA643284 | ENA |

REPOSITORIES: ENA

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Aflatoxin B1 attenuates endocrine function, protein synthesis and energy production of human primary trophoblast

Project description:Aflatoxin B1 (AFB1) is a mycotoxin produced by Aspergillus flavus and A. parasiticus. AFB1 targeted gene expression profiles were determined in human primary trophoblast cells, isolated from full term placentae after delivery, and exposed to 1 µM AFB1 for 72 hours. Gene expression profiling conducted with human HT-12 expression beadchips

2020-12-31 | GSE153590 | GEO

Early target genes of aflatoxin B1 in human hepatic cells

Project description:Comparison of gene expression profiles induced by the mycotoxin, aflatoxin B1 (AFB1), in primary human hepatocytes and HepaRG cells. Initial mechanisms involved in the complex multistep process leading to malignant transformation by chemicals remain largely unknown. We have analysed changes in gene expression profiles in primary human hepatocytes and differentiated human hepatoma HepaRG cells after a 24 h treatment with 0.05 or 0.25µM aflatoxin B1 (AFB1), a potent genotoxic hepatocarcinogen.

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Early target genes of aflatoxin B1 in human hepatic cells

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Agilent zebrafish V3 array 4´44K microarray-Aflatoxin B1 treated with 6-48 hpf zebrafish embryos

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Genome-Scale CRISPR Knockout Screening Identifies BACH1 as a Key Regulator of Aflatoxin B1-Induced Oxidative Damage [CRISPR screening]

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2022-03-25 | GSE199384 | GEO

Yeast Genomic Expression Patterns of PTC1 null mutant in Response to Aflatoxin B1 (AFB1)

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Liver and cecum from mice exposed to aflatoxin B1 (AFB1) and/or Helicobacter hepaticus

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Transcriptional Responses in Livers of Adult and Newborn Mice to Aflatoxin B1

Project description:Susceptibility to the hepatocarcinogen Aflatoxin B1 (AFB1) varies among species and with age. Mice are refractory to carcinogenic and toxic effects of AFB1; however, B6C3F1 mice show transient sensitivity if dosed shortly after birth. We compared age-related differences in gene expression and transcriptional responses to AFB1 in livers of newborn (4-day-old) and adult mice. Keywords: Transcriptional response to a carcinogen

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Aflatoxin B1 exposure induces epigenetic mechanisms in primary human hepatocytes revealing novel biological processes associated with hepatocellular carcinoma (Affymetrix)

Project description:The study investigated differential gene expression, microRNA expression and DNA methylation changes in a pool of primary human hepatocyte RNA and DNA following 5 days of repetitive exposure to a low (LD) or moderate (MD) dose of aflatoxin B1 or DMSO. Three biological replicates per compound/solvent.

2016-05-10 | GSE67002 | GEO

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