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The alteration of circulating exosomal mRNAs in acute myocardial infarction is associated with inflammation response

ABSTRACT: The alteration of circulating exosomal mRNAs in acute myocardial infarction is associated with inflammation response

PROVIDER: PRJNA670083 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12849255_1.fastq.gz	Fastqsanger.gz
	SRR12849255_2.fastq.gz	Fastqsanger.gz
	SRR12849256_1.fastq.gz	Fastqsanger.gz
	SRR12849256_2.fastq.gz	Fastqsanger.gz
	SRR12849257_1.fastq.gz	Fastqsanger.gz

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The alteration of circulating exosomal mRNAs in acute myocardial infarction is associated with inflammation response

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Project description:This study demonstrated that there were a number of dysregulated circRNAs in exosomes from OSA with AMI patients, which might be effectively served as a promising diagnostic biomarker and therapeutic targets. Objectives: Circular RNAs (circRNAs) are recently identified as a class of non-coding RNAs that participate in the incidence of acute myocardial infarction(AMI)

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Project description:Background: Although many cardiovascular disease studies have focused on the microRNAs of circulating exosomes, the profile and the potential clinical diagnostic value of plasma exosomal long RNAs (exoLRs) are unknown for acute myocardial infarction (AMI). Methods: In this study, the exoLR profile of 10 AMI patients, eight stable coronary artery disease (CAD) patients, and 10 healthy individuals was assessed by RNA sequencing. Bioinformatic approaches were used to investigate the characteristics and potential clinical value of exoLRs. Results: Exosomal mRNAs comprised the majority of total exoLRs. Immune cell types analyzed by CIBERSORT showed that neutrophils and monocytes were significantly enriched in AMI patients, consistent with clinical baseline values. Biological process enrichment analysis and co-expression network analysis demonstrated neutrophil activation processes to be enriched in AMI patients. Furthermore, two exosomal mRNAs, ALPL and CXCR2, were identified as AMI biomarkers that may be useful for evaluation of the acute inflammatory response mediated by neutrophils. Conclusions: ExoLRs were assessed in AMI patients and found to be associated with the acute inflammatory response mediated by neutrophils. Exosomal mRNAs, ALPL and CXCR2, were identified as potentially useful biomarkers for the study of AMI.

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