Myocardial infarction in Reg3beta knock-out mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thomas Boettger
PROVIDER: E-MTAB-2561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.
Lörchner Holger H Pöling Jochen J Gajawada Praveen P Hou Yunlong Y Polyakova Viktoria V Kostin Sawa S Adrian-Segarra Juan M JM Boettger Thomas T Wietelmann Astrid A Warnecke Henning H Richter Manfred M Kubin Thomas T Braun Thomas T
Nature medicine 20150309 4
Cardiac healing after myocardial ischemia depends on the recruitment and local expansion of myeloid cells, particularly macrophages. Here we identify Reg3β as an essential regulator of macrophage trafficking to the damaged heart. Using mass spectrometry-based secretome analysis, we found that dedifferentiating cardiomyocytes release Reg3β in response to the cytokine OSM, which signals through Jak1 and Stat3. Loss of Reg3β led to a large decrease in the number of macrophages in the ischemic heart ...[more]
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