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MRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [mRNA-seq dataset]

ABSTRACT: mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [mRNA-seq dataset]

PROVIDER: PRJNA673413 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12952889_1.fastq.gz	Fastqsanger.gz
	SRR12952889_2.fastq.gz	Fastqsanger.gz
	SRR12952890_1.fastq.gz	Fastqsanger.gz
	SRR12952890_2.fastq.gz	Fastqsanger.gz
	SRR12952891_1.fastq.gz	Fastqsanger.gz

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [mRNA-seq dataset]

Project description:Ophiocordyceps sinensis (Berk.) Sacc., a complex of larval carcass (sclerotium) and stroma formed by the fungus of Hirsutella sinensis infecting Hepialidae insect larvae, whose fruiting body is also the main fungal structure used for taxonomic identification. However, the induction of fruiting body is still inefficient and the high cost resulting in the large-scale artificial cultivation of this fungus has been unsuccessful in China.In this study,important factors and target genes associated with the fruiting body induction during the development of O. sinensis were identified, providing a basic molecular mechanism for facilitating the large-scale artificial cultivation of O. sinensis.

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [miRNA-seq dataset]

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis

Project description:mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [miRNA-seq dataset]

Project description:mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis [miRNA-seq dataset]

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting body in Ophiocordyceps sinensis.

Project description:Ophiocordyceps sinensis has been a source of valuable materials in traditional Asian medicine for over two thousand years. With recent global warming and overharvest, however, the availability of these wild fungi has decreased dramatically. While fruiting body of O. sinensis has been artificially cultivated, the molecular mechanisms that govern the induction of fruiting body at the transcriptional and post-transcriptional levels are unclear. In this study, we carried out both mRNA and small RNA sequencing to identify crucial genes and miRNA-like RNAs (milRNAs) involved in the development of fruiting body. A total of 2875 differentially expressed genes (DEGs), and 71 differentially expressed milRNAs (DEMs) were identified among the mycoparasite complex, the sclerotium (ST) and the fruiting body stage. Functional enrichment and Gene Set Enrichment Analysis indicated that the ST had increased oxidative stress and energy metabolism and that mitogen-activated protein kinase signaling might induce the formation of fruiting body. Integrated analysis of DEGs and DEMs revealed that n_os_milR16, n_os_milR21, n_os_milR34, and n_os_milR90 could be candidate milRNAs that regulate the induction of fruiting body. This study provides transcriptome-wide insight into the molecular basis of fruiting body formation in O. Sinensis and identifies potential candidate genes for improving induction rate.

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Snowball-like mushroom morphologies and a novel gene family required for fruiting body development

Project description:The morphogenesis of sexual fruiting bodies of fungi is a complex process determined by a genetically encoded programme. Fruiting bodies reached highest complexity levels in the Agaricomycetes, yet, the underlying genetics is currently poorly known. In this work, we functionally characterised an unannotated gene we term snb1, whose expression level increases rapidly during fruiting body initiation. According to phylogenetic analyses, orthologues of snb1 are present in almost all Agaricomycetes and may represent a novel conserved gene family that plays a substantial role in fruiting body development. We disrupted snb1 using CRISPR/Cas9 in the agaricomycete model organism Coprinopsis cinerea. Snb1 mutants formed unique, snowball-shaped, rudimentary fruiting bodies that could not differentiate caps, stipes and lamellae. We took advantage of this phenotype to study fruiting body differentiation using RNA-Seq analyses. This revealed a multitude of differentially regulated genes and gene families that may be related to tissue differentiation and the formation of structures. Taken together, the novel gene family of snb1 and the differentially expressed genes in the snb1 mutants provide valuable insights into the complex mechanisms underlying tissue differentiation in the Agaricomycetes.

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mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting bodies in Ophiocordyceps Sinensis

Project description:This SuperSeries is composed of the SubSeries listed below.

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