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Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

ABSTRACT: Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

PROVIDER: PRJNA675904 | ENA |

REPOSITORIES: ENA

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Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

Project description:Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is a well-documented feature in Alzheimer’s disease (AD). Herein, we investigated neuro-inflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuro-immune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk.

2020-12-08 | GSE161142 | GEO

Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

2020-12-08 | GSE161233 | GEO

Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

Project description:Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

| PRJNA675652 | ENA

Microarray analysis of RNA stability in mouse Neuro-2A cells

Project description:Microarray analysis of RNA stability in mouse Neuro-2A cells

2011-01-24 | E-MTAB-952 | biostudies-arrayexpress

mRNA expression of mid-old fibroblasts co-cultured with young and mid-old fibroblasts

Project description:Examination of the difference in mRNA expression profile between mid-old fibroblasts co-cultured with mid-old fibroblasts and mid-old fibroblasts co-cultured with young fibroblasts

2023-05-19 | GSE232425 | GEO

Mid-Cayman Rise

Project description:Subseafloor microbes at Mid-Cayman Rise

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Identification of the binding DNA of ONECUT2 by ChIP in Neuro-2a cells

Project description:These ChIP-seq analyses identified binding DNAs of ONEUCT2 in Neuro-2a (mouse neuroblastoma)cells. We overexpressed OC2ΔHOX (a gain-of-function mutant) in Neuro-2a cells, and infected the cells with HSV-1 at 40 hours post transfection. Samples infected for 5 hours were sequenced by ChIP for binding DNAs of the OC2 mutant in Neuro-2a cells.

2023-09-18 | GSE241863 | GEO

Aldosteroid effects on Neuro-retina

Project description:Aldosteroid effects on Neuro-retina in Rat Model

| PRJEB29571 | ENA

TP01 mid-L3

Project description:Timepoint 01 wild type mid-L3 larvae vs mixed stage reference Keywords: other

2003-12-31 | GSE726 | GEO

RNAseq of wild type and GDF11-/- Neuro-2a cells

Project description:Growth differentiation factor 11 (GDF11), is one of the members of transforming growth factor β (TGFβ) superfamily. We set out to unequivocally reveal the effect of endogenous GDF11 on biological process by adopting CRISPR/Cas9 gene knockout strategy to specifically delete GDF11 gene in Neuro-2a cells. We analyze mRNA profiles of differentially genes in wild type (WT) and GDF11 knockout (GDF11-/-) Neuro-2a cells by using RNA-seq technology. The RNA-seq data reported here provide a fundamental materials and evidence for investigations of biological function of GDF11.

2021-10-06 | GSE167538 | GEO

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