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Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

ABSTRACT: Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

PROVIDER: PRJNA675652 | ENA |

REPOSITORIES: ENA

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Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [P3]

Project description:Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is a well-documented feature in Alzheimer’s disease (AD). Herein, we investigated neuro-inflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuro-immune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk.

2020-12-08 | GSE161142 | GEO

Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

2020-12-08 | GSE161233 | GEO

Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

Project description:Emergence of Dynamic Neuro-Immune Profile During Mid-life Aging in the Female Brain: Implications for Alzheimer’s Disease Risk [Hot flash]

| PRJNA675904 | ENA

Streptomyces sp. P3 strain:P3

Project description:Streptomyces sp. P3 strain:P3 Genome sequencing

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Clostridioides difficile P3 strain:P3

Project description:Clostridioides difficile P3 strain:P3 Genome sequencing and assembly

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Transcription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines

Project description:The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to identify genes that may contribute to the increase in immune resistance. Experiment Overall Design: Four experimental replicates were prepared for each cell line. P0 is the control cell line, and P3 is the experimental/resistant cell line.

2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress

Identification of tumor immune evasion mechanism using P0 and P3 cell lines

2005-12-06 | GSE2774 | GEO

Flavonifractor plautii strain:P3

Project description:Flavonifractor plautii P3 genome sequencing

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Microarray analysis of RNA stability in mouse Neuro-2A cells

Project description:Microarray analysis of RNA stability in mouse Neuro-2A cells

2011-01-24 | E-MTAB-952 | biostudies-arrayexpress

Mapping of the nuclear PI(3,4,5)P3 interactome in DLD1 and SW480 cells

Project description:Phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) is a lipid second messenger produced by class I phosphoinositide 3-kinases (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2). Although typically associated with the plasma membrane, it is now appreciated that PI(3,4,5)P3 generation also occurs in the nucleus to regulate a variety of biological functions. Using a PI(3,4,5)P3-specific GST-GRP1PH domain reporter and immunofluorescence microscopy, we have found that DLD1 and SW480 colorectal cancer (CRC) cells exhibit pronounced nuclear staining of PI(3,4,5)P3. To characterise the nuclear PI(3,4,5)P3 interactome in DLD1 and SW480 cells, we performed affinity pull-down experiments on nuclear extracts using a ω-amino analogue of phosphatidylinositol 3,4,5 -triphosphate (PI(3,4,5)P3 immobilised onto Affi-gel10 beads. Gel fractionation and LC/MS-MS analysis was performed to reduce sample complexity and increase resolution, with samples run on a LTQ Orbitrap Elite mass spectrometer. DLD1 and SW480 cells were both analysed in four independent biological replicates. A protein was considered a member of the nuclear PI(3,4,5)P3 interactome if it was identified in at least two experiments (with at least two peptides, FDR of 1%) in both cell lines, yielding a total of 1237 unique proteins (representing 1103 genes for DLD1 and 1001 genes for SW480 cells).

2023-05-10 | PXD021936 | Pride

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