Dataset Information

RNA-seq of temperature sensitive alleles of splicing factors in fission yeast

ABSTRACT: RNA-seq of temperature sensitive alleles of splicing factors in fission yeast

PROVIDER: PRJNA677902 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR13040600_1.fastq.gz	Fastqsanger.gz
	SRR13040600_2.fastq.gz	Fastqsanger.gz
	SRR13040601_1.fastq.gz	Fastqsanger.gz
	SRR13040601_2.fastq.gz	Fastqsanger.gz
	SRR13040602_1.fastq.gz	Fastqsanger.gz

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Project description:Gould2011 - Temperature Sensitive Circadian Clock This model is a temperature sensitive version of Pokhilko et al. 2010 (PMID: 20865009), which is BIOMD0000000273 in BioModels. This model is described in the article: Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures. Gould PD, Ugarte N, Domijan M, Costa M, Foreman J, Macgregor D, Rose K, Griffiths J, Millar AJ, Finkenstädt B, Penfield S, Rand DA, Halliday KJ, Hall AJ. Mol. Syst. Biol. 2013; 9: 650 Abstract: Circadian clocks exhibit 'temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis. We show that blue light is essential for this, suggesting that the effects of light and temperature interact or converge upon common targets in the circadian clock. Our data demonstrate that two cryptochrome photoreceptors differentially control circadian period and sustain rhythmicity across the physiological temperature range. In order to test the hypothesis that the targets of light regulation are sufficient to mediate temperature compensation, we constructed a temperature-compensated clock model by adding passive temperature effects into only the light-sensitive processes in the model. Remarkably, this model was not only capable of full temperature compensation and consistent with mRNA profiles across a temperature range, but also predicted the temperature-dependent change in the level of LATE ELONGATED HYPOCOTYL, a key clock protein. Our analysis provides a systems-level understanding of period control in the plant circadian oscillator. This model is hosted on BioModels Database and identified by: BIOMD0000000564. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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RNA-seq of temperature sensitive alleles of splicing factors in fission yeast

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