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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

ABSTRACT: KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

PROVIDER: PRJNA701035 | ENA |

REPOSITORIES: ENA

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Similar Datasets

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

| PRJNA701036 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

| PRJNA701039 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq timecourse)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq timecourse)

| PRJNA701038 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

| PRJNA701040 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-17 | GSE166486 | GEO

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

Project description:We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

2021-03-17 | GSE166482 | GEO

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

Project description:We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

2021-03-17 | GSE166481 | GEO

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

Project description:We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

2021-03-17 | GSE166485 | GEO

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq timecourse)

Project description:We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

2021-03-17 | GSE166484 | GEO

Lysine Demethylase 6b (Kdm6b) is essential for proper generation of effector CD8+ T lymphocytes by inducing chromatin accessibility in effector-associated genes

Project description:The transcriptional and epigenetic regulation of CD8+ T cell differentiation is critical for balancing pathogen eradication and long-term immunity by effector and memory CTLs. Here, we demonstrate that the Lysine Demethylase 6b (Kdm6b) is essential for the proper generation and function of effector CD8+ T cells during acute infection and tumor eradication. We found that cells lacking Kdm6b (either T cell-specific KO or knockdown utilizing shRNA strategies) show an enhanced generation of memory precursor and early effector cells upon acute viral infection in a cell-intrinsic manner. We also demonstrate that Kdm6b is indispensable for proper effector functions and tumor protection, and that memory CD8+ T cells lacking Kdm6b displayed a defective recall response. Mechanistically, we identified that Kdm6b, through induction of chromatin accessibility in key effector-associated gene loci, allows for the proper generation of effector CTLs. Our results pinpoint the essential function of Kdm6b in allowing chromatin accessibility in effector-associated genes, and identify Kdm6b as a potential target for therapeutics in diseases with dysregulated effector responses.

2021-02-25 | GSE161842 | GEO

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