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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors

ABSTRACT: Identification of 22 novel susceptibility loci associated with testicular germ cell tumors

PROVIDER: PRJNA732179 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14627626_1.fastq.gz	Fastqsanger.gz
	SRR14627626_2.fastq.gz	Fastqsanger.gz
	SRR14627627_1.fastq.gz	Fastqsanger.gz
	SRR14627627_2.fastq.gz	Fastqsanger.gz
	SRR14627628_1.fastq.gz	Fastqsanger.gz

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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors [ATAC-seq]

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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors [Capture C]

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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors [ATAC-seq]

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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors [Capture C]

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Identification of 22 susceptibility loci associated with testicular germ cell tumors.

Project description:Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men with a polygenic risk score (PRS) in the 95th percentile have a 6.8-fold increased risk of TGCT compared to men with median scores. Among men with independent TGCT risk factors such as cryptorchidism, the PRS may guide screening decisions with the goal of reducing treatment-related complications causing long-term morbidity in survivors. These findings emphasize the interconnected nature of two known pathways that promote TGCT susceptibility: male germ cell development within its somatic niche and regulation of chromosomal division and structure, and implicate an additional biological pathway, mRNA translation.

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Identification of 22 novel susceptibility loci associated with testicular germ cell tumors

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-01 | GSE175368 | GEO

Testicular germ cell tumors and their histological subgroups

Project description:Normal, premalignant and various histological subtypes of testicular germ cell tumor (TGCT) tissues were hybridized against Universal Human Reference RNA (Stratagene) onto Agilent 60mer oligo microarrays (GEO accession no GPL885). In vitro time series of two TGCT cell lines, NTERA2 and 2102Ep, treated with retinoic acid for 0, 3, and 7 days were also included. The data set (30 hybridizations) is particularly useful for comparisons between various histological subtypes of TGCT versus each other or versus normal testis. Keywords = 2102Ep Keywords = Agilent oligo microarrays Keywords = carcinoma in situ Keywords = choriocarcinoma Keywords = development Keywords = developmental biology Keywords = differenciation Keywords = embryogenesis Keywords = embryonal carcinoma Keywords = homo sapiens Keywords = human Keywords = human development Keywords = intratubular germ cell tumor Keywords = nonseminoma Keywords = NTera2 Keywords = pluripotency Keywords = pluripotent Keywords = retinoic acid Keywords = seminoma Keywords = teratocarcinoma Keywords = teratoma Keywords = testis Keywords = testicular germ cell tumor Keywords = testicular neoplasm Keywords = totipotency Keywords = totipotent Keywords = undifferentiated Keywords = universal human reference RNA (Stratagene) Keywords = yolk sac tumor Keywords: other

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