Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [scRNA-seq]

ABSTRACT: ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [scRNA-seq]

PROVIDER: PRJNA737410 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14804657_1.fastq.gz	Fastqsanger.gz
	SRR14804657_2.fastq.gz	Fastqsanger.gz
	SRR14804658_1.fastq.gz	Fastqsanger.gz
	SRR14804658_2.fastq.gz	Fastqsanger.gz
	SRR14804659_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [scRNA-seq]

Project description:ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric glioblastoma (GBM) and IDH-mutant grade 2/3 adult glioma. Previous work has shown that ATRX-deficient GBM cells show enhanced sensitivity to irradiation, but the etiology remains unclear. We found that ATRX binds regulatory elements of cell cycle phase transition genes in GBM cells, and there is a marked reduction in Checkpoint Kinase 1 (CHEK1) expression with ATRX loss, leading to early release of G2/M entry after irradiation. ATRX-deficient cells exhibit enhanced activation of master cell cycle regulator ATM with irradiation. Mice intra-cranially implanted with ATRX-deficient GBM cells demonstrate doubling of median survival compared to the ATRX-Wild Type controls when treated with ATM inhibitor AZD0156 and radiation. This study demonstrates that ATRX-deficient high-grade gliomas (HGGs) display epigenetic dysregulation of cell cycle phase transitions, which opens a new window for therapies targeting this unique phenotype.

2022-01-18 | GSE178114 | GEO

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [RNA-seq]

2022-01-18 | GSE178113 | GEO

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition

Project description:ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition

| PRJNA737405 | ENA

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [RNA-seq]

Project description:ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition [RNA-seq]

| PRJNA737409 | ENA

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [Atrx ChIP]

Project description:The chromatin regulator ATRX is inactivated in large subsets of adult and pediatric glioma. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear. We found that Atrx loss, especially when coupled with Tp53 inactivation, promoted cell motility and modulated differentiation state in primary murine neuroepithelial progenitors, recapitulating characteristic disease phenotypes and molecular features. Moreover, Atrx deficiency induced widespread shifts in chromatin accessibility, histone composition, and gene transcription at vacant Atrx binding sites distributed across the genome. Finally, target genes mediating Atrx-deficient phenotypes in vitro exhibited similarly selective misexpression in ATRX-mutant human glioma tissues and cell lines. These findings demonstrate that, in appropriate physiological contexts, ATRX deficiency and its epigenomic sequelae are sufficient to induce disease-defining oncogenic phenotypes.

2017-12-31 | GSE100462 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [RNA-seq]

2017-12-31 | GSE100464 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [H3.3 ChIP]

2017-12-31 | GSE100463 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [ATAC-seq]

2017-12-31 | GSE100461 | GEO

Profiling of SF188 ATRX isogenic glioma cells

Project description:Methylation profiling of SF188 paediatric high grade glioma cell line isogenic clones carrying CRISR/Cas9 frameshift deletions in ATRX

2019-06-01 | E-MTAB-7800 | biostudies-arrayexpress

ATRX loss in glioma results in epigenetic dysregulation of cell cycle phase transition

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-01-18 | GSE178116 | GEO