Homo sapiens
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ABSTRACT:
PROVIDER: PRJNA75455 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK
| PRJNA75453 | ENA
Project description:<p>Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls. The other parents and the remaining cases and controls are available by a separate application process through NIDDK (dbGaP <a href="./study.cgi?id=phs000088">phs000088</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK</i>). Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form available at <a href="http://www.jdrf.org/index.cfm?fuseaction=home.viewPage&page_id=B9C33021-1321-C834-0382E079E7865807">Juvenile Diabetes Research Foundation</a>.</p> <p><b>Consent groups and participant set</b><br/> <ul> <li>Diabetic complications only (DCO): 1825 (904 cases, 881 controls, 40 others)</li> </ul> </p>
| phs000018.v1.p1 | EGA
Project description:Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes.
A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut
kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria
and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD
includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible
as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls
(dbGaP <a href="./study.cgi?id=phs000018">phs000018</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN</i>).
The other parents and the remaining cases and controls are available by a separate application process through NIDDK. Interested investigators may
request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form
available at <a href="http://www.niddkrepository.org">http://www.niddkrepository.org</a> or by contacting the Juvenile Diabetes Research Foundation.
| phs000088.v1.p1 | EGA
Project description:<p>Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls. The other parents and the remaining cases and controls are available by a separate application process through NIDDK (dbGaP <a href="./study.cgi?id=phs000088">phs000088</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK</i>). Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form available at <a href="http://www.jdrf.org/index.cfm?fuseaction=home.viewPage&page_id=B9C33021-1321-C834-0382E079E7865807">Juvenile Diabetes Research Foundation</a>.</p> <p><b>Consent groups and participant set</b><br/> <ul> <li>Diabetic complications only (DCO): 1825 (904 cases, 881 controls, 40 others)</li> </ul> </p>
| phs000018 | dbGaP
Project description:Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes.
A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut
kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria
and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD
includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible
as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls
(dbGaP <a href="./study.cgi?id=phs000018">phs000018</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN</i>).
The other parents and the remaining cases and controls are available by a separate application process through NIDDK. Interested investigators may
request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form
available at <a href="http://www.niddkrepository.org">http://www.niddkrepository.org</a> or by contacting the Juvenile Diabetes Research Foundation.
| phs000088 | dbGaP
Project description:GoKinD: Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
| PRJNA75399 | ENA
Project description:GoKinD: Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
| PRJNA75397 | ENA
Project description:Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice. RNA isolated from kidney glomeruli of DBA/2 and C57BL/6 mice, with or without 4 weeks diabetes induced by streptozotocin.
2016-07-22 | E-GEOD-84663 | biostudies-arrayexpress
Project description:Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice.
2016-07-22 | GSE84663 | GEO
Project description:Despite research progresses, the chance to accurately predict the risk for diabetic nephropathy (DN) is still poor. Our goal is to develop new predictive tools of nephropathy starting from urine, which can be easily obtained using noninvasive procedures and it is directly related to kidney. In this study, urine from children with recent diagnosis of type 1 diabetes was subjected to proteomic analysis in comparison to age-matched controls. Targeted confirmation was performed on children with a longer history of diabetes using Western Blotting and applying a urinary lipidomic approach. To definitively understand whether the observed alterations could be related to diabetic nephropathy, urine from diabetic adults with or without albuminuria, which is an indication of nephropathy, was also examined. Our results showed that lipid metabolisms of prostaglandin and ceramide, which are significantly and specifically modified in association with DN, are already altered in children with a recent diabetes diagnosis.
2018-11-04 | PXD011183 | Pride