Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic Study on Proteinuria in Type-2 Diabetes

ABSTRACT: Genetic Study on Proteinuria in Type-2 Diabetes

PROVIDER: PRJNA75589 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Project description:Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, while beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alter the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role for beta cell fragility in genetic predisposition to diabetes.

2016-02-24 | PXD000859 | Pride

Homo sapiens

Project description:Genetic Study on Proteinuria in Type-2 Diabetes

| PRJNA75591 | ENA

Type 1 Diabetes Genetics Consortium (T1DGC) ImmunoChip Study

Project description:Type 1 Diabetes Genetics Consortium (T1DGC) ImmunoChip Study

| PRJNA285005 | ENA

Diabetes Heart Study

Project description:Diabetes Heart Study

| PRJNA300330 | ENA

SEARCH for Diabetes in Youth Study - Genetic Risk Score

Project description:SEARCH for Diabetes in Youth Study - Genetic Risk Score

| PRJNA782026 | ENA

SEARCH for Diabetes in Youth Study - Genetic Risk Score

Project description:SEARCH for Diabetes in Youth Study - Genetic Risk Score

| PRJNA782027 | ENA

Genetic Study on Nephropathy in Type-2 Diabetes

Project description:<p>A collection of patients with type-2 diabetes was collected at the Joslin Diabetes Center. Patients were categorized to a group of cases with diabetic nephropathy, and a group of controls with normoalbuminuria. From these groups, 173 cases and 177 controls were randomly selected for a genome-wide association study.</p>

| phs000302.v1.p1 | EGA

Genetic variants associated with development of colorectal cancer, type 1 diabetes, Hodgkin lymphoma and Diffuse large B-cell lymphoma

Project description:In our genome-wide association study, we searched for an association of genetic variants with colorectal cancer, type 1 diabetes, Hodgkin lymphoma and Diffuse large B-cell lymphoma among Polish population.

2021-07-02 | GSE156411 | GEO

Droplet based single cell RNA sequencing profiles of a murine model of type-1 diabetes

Project description:Diabetic kidney disease remains the leading cause of end-stage renal disease, affecting ~30% of patients with long-standing type 1 and type 2 diabetes, and is characterized by proteinuria and gradual loss of kidney function. There is intense interest in understanding the responses of the many cell types present in the kidney to the diabetic milleu. In this study, we present single cell transcriptomes of renal cortex samples of wild-type and diabetic (C57BL/6-Ins2Akita/J) mice using Drop-Seq.

2018-03-14 | GSE111752 | GEO

Type 1 Diabetes Genetics Consortium (T1DGC): Multi-Ethnic ImmunoChip Study

Project description:Type 1 Diabetes Genetics Consortium (T1DGC): Multi-Ethnic ImmunoChip Study

| PRJNA738974 | ENA