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Rapid Acceleration of Diagnostics - Radical (RADx-rad): A Rapid Breathalyzer Diagnostics Platform for COVID-19

ABSTRACT: Rapid Acceleration of Diagnostics - Radical (RADx-rad): A Rapid Breathalyzer Diagnostics Platform for COVID-19

PROVIDER: PRJNA759295 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Radical (RADx-rad): A Rapid Breathalyzer Diagnostics Platform for COVID-19

Project description:Rapid Acceleration of Diagnostics - Radical (RADx-rad): A Rapid Breathalyzer Diagnostics Platform for COVID-19

| PRJNA759296 | ENA

Molecular Determinants for RNA Polymerase II Elongation Rate and Acceleration

Project description:Recent studies reveal a striking phenomenon that RNA Polymerase II (Pol II) appears to travel on gene body in an accelerated fashion, but the mechanism has remained unknown. We performed synchronized transcription coupled with deep sequencing, observing an inverse relationship between initial rate and acceleration in different cell types. We directly tested several correlative events and detected a positive contribution of the splicing commitment factor SRSF2 to Pol II acceleration, suggesting a functional benefit of co-transcriptional pre-mRNA splicing in transcription elongation. Unexpectedly, we found that perturbation of Pol II Ser2 phosphorylation had little impact on Pol II elongation or acceleration. While H3K79me2 has been positively correlated with Pol II elongation, we showed that reduction of this histone modification event actually accelerated Pol II elongation. Together, these data suggest a combined effect of gradual gain-of-competence and gradual lost-of-epigenetic barriers as the mechanism for accelerated Pol II elongation. DRB time-course releasing assay under functional perturbation

2015-12-31 | E-GEOD-66021 | biostudies-arrayexpress

Establish a rapid and efficient chemical reprogramming platform (RRBS)

Project description:Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To further investigate the mechemisms and draw an epigenetic maps during the rapid chemical reprogramming, we performed time-course RNA-seq, ATAC-seq, RRBS and CUT&Tag (H3K4me3, H3K18la, H3K9me3, H3K27me3 and H3K27ac).

2023-05-03 | GSE188831 | GEO

Establish a rapid and efficient chemical reprogramming platform (CUT&Tag)

2023-05-03 | GSE188826 | GEO

Establish a rapid and efficient chemical reprogramming platform (ATAC-Seq)

2023-05-03 | GSE188824 | GEO

Establish a rapid and efficient chemical reprogramming platform [scRNA-Seq]

Project description:Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To further investigate the mechemisms and draw an epigenetic maps during the rapid chemical reprogramming, we performed time-course RNA-seq, ATAC-seq, RRBS, CUT&Tag (H3K4me3, H3K18la, H3K9me3, H3K27me3 and H3K27ac) and scRNA-seq.

2023-05-03 | GSE218855 | GEO

Establish a rapid and efficient chemical reprogramming platform (RNA-Seq)

2023-05-03 | GSE188830 | GEO

Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy

Project description:This SuperSeries is composed of the following subset Series: GSE26022: [Gene Expression Training Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26242: [Gene Expression Validation Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26245: [miRNA Training Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26247: [miRNA Validation Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy Refer to individual Series

2011-06-01 | E-GEOD-26367 | biostudies-arrayexpress

Sepsis diagnostics using MinION

Project description:Real-time sequencing-based diagnostics of bacteremia in septic patients

| PRJEB28340 | ENA

Establish a rapid and efficient chemical reprogramming platform (RNA-Seq II)

Project description:Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To further investigate the mechemisms and draw an epigenetic maps during the rapid chemical reprogramming, we performed time-course RNA-seq, ATAC-seq, RRBS, CUT&Tag (H3K4me3, H3K18la, H3K9me3, H3K27me3 and H3K27ac) and scRNA-seq.

2023-05-03 | GSE220554 | GEO

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