Homo sapiens
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PROVIDER: PRJNA75975 | ENA |
REPOSITORIES: ENA
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Project description:Genetics of Nephropathy, an International Effort (UK GoKinD/All Ireland Diabetic Nephropathy), GENIE
| PRJNA75973 | ENA
Project description:<p>Diabetic kidney disease, or diabetic nephropathy (DN), is one of the leading causes of end-stage renal disease in the United States and worldwide. DN is a common complication of long-standing type 1 and type 2 diabetes. The clinical course is characterized by development of proteinuria and gradual loss of kidney function. Although existing treatments that decrease proteinuria have been shown to moderately abate progression of diabetic kidney disease, many affected patients, who do not die from cardiovascular disease, go on to develop terminal renal failure, necessitating costly renal replacement therapies, such as dialysis and renal transplantation. Type 1 diabetes (T1D) can have its onset in childhood and affected individuals often develop end-stage renal disease in early adulthood, leading to further loss of quality of life. The genetic basis of the disease is not well understood.</p> <p>The GENIE (<b>GE</b>netics of <b>N</b>ephropathy an <b>I</b>nternational <b>E</b>ffort) consortium was initiated to perform the most comprehensive and well powered DN susceptibility genome wide association study (GWAS) analysis to date, using the largest collection of type 1 diabetics with and without kidney disease across four study cohorts. The UK-ROI samples were genotyped as part of this project.</p> <p><b>UK-ROI Sample Description</b><br/> The UK-ROI collection consists of samples derived from the Republic of Ireland (Dr. Catherine Godson, PI, at University College, Dublin, Ireland) and the United Kingdom (Warren 3 and Genetics of Kidneys in Diabetes UK, <b>UK GoKinD</b>, Dr. Alexander P. Maxwell, PI, at Queen's University of Belfast, UK). All study subjects met the inclusion criteria: white individuals with T1D, diagnosed before 31 years of age, whose parents and grandparents were born in the British Isles.</p>
| phs000389 | dbGaP
Project description:GoKinD: Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
| PRJNA75399 | ENA
Project description:GoKinD: Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes
| PRJNA75397 | ENA
Project description:<p>Diabetic kidney disease, or diabetic nephropathy (DN), is one of the leading causes of end-stage renal disease in the United States and worldwide. DN is a common complication of long-standing type 1 and type 2 diabetes. The clinical course is characterized by development of proteinuria and gradual loss of kidney function. Although existing treatments that decrease proteinuria have been shown to moderately abate progression of diabetic kidney disease, many affected patients, who do not die from cardiovascular disease, go on to develop terminal renal failure, necessitating costly renal replacement therapies, such as dialysis and renal transplantation. Type 1 diabetes (T1D) can have its onset in childhood and affected individuals often develop end-stage renal disease in early adulthood, leading to further loss of quality of life. The genetic basis of the disease is not well understood.</p> <p>The GENIE (<b>GE</b>netics of <b>N</b>ephropathy an <b>I</b>nternational <b>E</b>ffort) consortium was initiated to perform the most comprehensive and well powered DN susceptibility genome wide association study (GWAS) analysis to date, using the largest collection of type 1 diabetics with and without kidney disease across four study cohorts. The UK-ROI samples were genotyped as part of this project.</p> <p><b>UK-ROI Sample Description</b><br/> The UK-ROI collection consists of samples derived from the Republic of Ireland (Dr. Catherine Godson, PI, at University College, Dublin, Ireland) and the United Kingdom (Warren 3 and Genetics of Kidneys in Diabetes UK, <b>UK GoKinD</b>, Dr. Alexander P. Maxwell, PI, at Queen's University of Belfast, UK). All study subjects met the inclusion criteria: white individuals with T1D, diagnosed before 31 years of age, whose parents and grandparents were born in the British Isles.</p>
| phs000389.v1.p1 | EGA
Project description:<p>Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls. The other parents and the remaining cases and controls are available by a separate application process through NIDDK (dbGaP <a href="./study.cgi?id=phs000088">phs000088</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK</i>). Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form available at <a href="http://www.jdrf.org/index.cfm?fuseaction=home.viewPage&page_id=B9C33021-1321-C834-0382E079E7865807">Juvenile Diabetes Research Foundation</a>.</p> <p><b>Consent groups and participant set</b><br/> <ul> <li>Diabetic complications only (DCO): 1825 (904 cases, 881 controls, 40 others)</li> </ul> </p>
| phs000018 | dbGaP
Project description:Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes.
A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut
kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria
and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD
includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible
as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls
(dbGaP <a href="./study.cgi?id=phs000018">phs000018</a> <i>Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN</i>).
The other parents and the remaining cases and controls are available by a separate application process through NIDDK. Interested investigators may
request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form
available at <a href="http://www.niddkrepository.org">http://www.niddkrepository.org</a> or by contacting the Juvenile Diabetes Research Foundation.
| phs000088 | dbGaP
Project description:Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK
| PRJNA75455 | ENA