Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Characterizing the novel mutations associated with bedaquiline resistance in Mycobacterium tuberculosis

PROVIDER: PRJNA766993 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR16295800_1.fastq.gz	Fastqsanger.gz
	SRR16295800_2.fastq.gz	Fastqsanger.gz
	SRR16295801_1.fastq.gz	Fastqsanger.gz
	SRR16295801_2.fastq.gz	Fastqsanger.gz
	SRR16295802_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 202

Similar Datasets

Global Gene expression data from Mycobacterium tuberculosis treated with new TB drug named Bedaquiline

Project description:Sirturo or Bedaquiline has been shown to inhibit the ATP synthase of Mycobacterium tuberculosis. We used microarrays to investigate compound-induced gene expression changes in general as well as effects on the transcription of the different ATP synthase genes and other metabolic pathways. Log phase Mycobacterium tuberculosis were cultivated in Middlebrook 7H9 broth and treated with 1 M-BM-5M Bedaquiline. We have extracted RNA from five different time-points after treatment: 0 min (T0), 30 min (T30), 60 min (T60), 180 min (T180) and 360 min (T360).

2014-03-03 | E-GEOD-43749 | biostudies-arrayexpress

Whole genome sequencing of Mycobacterium tuberculosis strains resistant to D-cycloserine

Project description:11 Mycobacterium tuberculosis mutants resistant to D-cycloserine were isolated in the laboratory. Genomic DNA was isolated and whole genomes were sequenced to perform SNP calling and identify possible mutations associated with resistance.

2018-12-28 | E-MTAB-5935 | biostudies-arrayexpress

Global Gene expression data from Mycobacterium tuberculosis treated with new TB drug named Bedaquiline

2014-03-03 | GSE43749 | GEO

Project description:Characterizing the gene mutations associated with resistance to gatifloxacin in Mycobacterium tuberculosis through whole-genome sequence

| PRJNA685530 | ENA

Mycobacterium tuberculosis

Project description:Non-gyrase Mutations Associated with Fluoroquinolone Resistance in Mycobacterium tuberculosis

| PRJNA200920 | ENA

Mycobacterium tuberculosis transcriptional response to Bedaquiline

Project description:Mycobacterium tuberculosis transcriptional response to Bedaquiline

| PRJNA701251 | ENA

Site-directed mutagenesis for bedaquiline resistance

Project description:SITE-DIRECTED MUTAGENESIS OF MYCOBACTERIUM TUBERCULOSIS AND FUNCTIONAL VALIDATION TO INVESTIGATE POTENTIAL BEDAQUILINE RESISTANCE CAUSING MUTATIONS

| PRJEB52049 | ENA

Project description:Novel Mutational Signatures Associated with Isoniazid Resistance in Mycobacterium tuberculosis

| PRJEB3390 | ENA

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

Project description:Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means that it is unclear whether antibiotics penetrate all mycobacteria-containing compartments in the cell. Here, we combined correlated light, electron, and ion microscopy to image the distribution of bedaquiline in infected human macrophages at submicrometer resolution. Bedaquiline accumulated primarily in host cell lipid droplets, but heterogeneously in mycobacteria within a variety of intracellular compartments. Furthermore, lipid droplets did not sequester antibiotic but constituted a transferable reservoir that enhanced antibacterial efficacy. Thus, strong lipid binding facilitated drug trafficking by host organelles to an intracellular target during antimicrobial treatment.

2020-12-07 | MTBLS959 | MetaboLights

Mycobacterium tuberculosis XDR case with bedaquiline and delamanid resistance WGS study

Project description:Mycobacterium tuberculosis XDR case with bedaquiline and delamanid resistance WGS study

| PRJEB9936 | ENA