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Comparison of transcriptomes reveals differential regulation at four different ages in Sika Deer testes

ABSTRACT: Comparison of transcriptomes reveals differential regulation at four different ages in Sika Deer testes

PROVIDER: PRJNA778637 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR16848205_1.fastq.gz	Fastqsanger.gz
	SRR16848205_2.fastq.gz	Fastqsanger.gz
	SRR16848206_1.fastq.gz	Fastqsanger.gz
	SRR16848206_2.fastq.gz	Fastqsanger.gz
	SRR16848207_1.fastq.gz	Fastqsanger.gz

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Comparison of miRNA transcriptomes reveals differential regulation from ten tissues and four development stages of Sika Deer

Project description:To elucidate the complex physiological process of the growth, development and immunity response of Sika Deer, this study evaluated the changes of miRNA profiles in the four developmental stages (juvenile, adolescence, adult and aged) of ten tissue (adrenal, antler, brain, heart, kidney, lung, liver, skeletal muscle, spleen and testes). The results showed that a total of 306 known miRNAs and 143 novel miRNAs were obtained. Many miRNAs displayed organ-specificity and age-specificity. The largest number of miRNAs were enriched in the brain, some of which were shared only between the brain and adrenal. These miRNAs were involved in maintaining specific functions within the brain and adrenal. Additionally, the adolescence-adult transition of Sika Deer was a crucial stage in its life cycle. In conclusion, our study provided abundant data support for the current research Sika Deer. It also contributes to understand the role of miRNAs play in regulating the growth, development and immunity response of Sika Deer.

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Comparison of miRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

Project description:To elucidate the complex physiological process of testis development and spermatogenesis in Sika deer, this study evaluated the changes of miRNA profiles in the four developmental stages of testis the juvenile (1-year-old), adolescence (3-year-old), adult (5-year-old) and aged (10-year-old) stages. The results showed that total total of 198 mature and 66 novel miRNAs were obtained. 88 (43 up and 45 down), 102 (44 up and 58 down), 54 (18 up and 36 down) DE miRNAs were identified in 3-vs.1-, 5-vs.3- and 10-vs.5-year-old testes, respectively. By integrating miRNA expression profiles, we predicted 69883 miRNA-mRNA interaction sites. The target genes were enriched by GO and KEGG pathways to obtain DE miRNA (miR-145, miR-140, miR-7, miR-26a, etc.), which play an important role in testis development and spermatogenesis. The data show that DE miRNAs could regulate testis developmental and spermatogenesis through signaling pathways, including MAPK signaling pathway, p53 signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, etc. It provides a useful resource for future studies on the role of miRNA regulation in testis development and spermatogenesis.

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Comparison of mRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

Project description:To elucidate the complex physiological process of testis development and spermatogenesis in Sika deer, this study evaluated the changes of mRNA profiles in the four developmental stages of testis the juvenile (1-year-old), adolescence (3-year-old), adult (5-year-old) and aged (10-year-old) stages. The results showed that total total of 23558 differentially expressed (DE) unigenes were obtained. 14918 (8413 up and 6505 down), 4988 (2453 up and 2535 down), 5681 (2929 up and 2752 down) DE unigenes were identified in 3-vs.1-, 5-vs.3- and 10-vs.5-year-old testes, respectively. By integrating mRNA expression profiles, we predicted 10790 mRNA-mRNA interaction sites. The target genes were enriched by GO and KEGG pathways to obtain DE mRNA (ALKBH5, Piwil, HIF1A, BRDT, etc.), which play an important role in testis development and spermatogenesis. The data show that DE mRNAs could regulate testis developmental and spermatogenesis through signaling pathways, including MAPK signaling pathway, p53 signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, etc. It provides a useful resource for future studies on the role of genes regulation in testis development and spermatogenesis.

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Comparison of miRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

Project description:Comparison of miRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

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Comparison of mRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

Project description:Comparison of mRNA transcriptomes reveals differential regulation at four different ages in Sika Deer testes

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Comparison of transcriptomes reveals differential regulation at four different ages in Sika Deer testes

Project description:This SuperSeries is composed of the SubSeries listed below.

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Altered expression in sika deer skeletal muscle with age

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