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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys [ATAC-seq]

ABSTRACT: A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys [ATAC-seq]

PROVIDER: PRJNA807320 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18042384_1.fastq.gz	Fastqsanger.gz
	SRR18042384_2.fastq.gz	Fastqsanger.gz
	SRR18042386_1.fastq.gz	Fastqsanger.gz
	SRR18042386_2.fastq.gz	Fastqsanger.gz
	SRR18042387_1.fastq.gz	Fastqsanger.gz

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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys [ATAC-seq]

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A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys.

Project description:Non-human primates are attractive laboratory animal models that accurately reflect both developmental and pathological features of humans. Here we present a compendium of cell types across multiple organs in cynomolgus monkeys (Macaca fascicularis) using both single-cell chromatin accessibility and RNA sequencing data. The integrated cell map enables in-depth dissection and comparison of molecular dynamics, cell-type compositions and cellular heterogeneity across multiple tissues and organs. Using single-cell transcriptomic data, we infer pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes. Furthermore, we identify various cell-specific cis-regulatory elements and construct organ-specific gene regulatory networks at the single-cell level. Finally, we perform comparative analyses of single-cell landscapes among mouse, monkey and human. We show that cynomolgus monkey has strikingly higher degree of similarities in terms of immune-associated gene expression patterns and cellular communications to human than mouse. Taken together, our study provides a valuable resource for non-human primate cell biology.

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