Dataset Information

Multisite proteome provides insights into the biology and prognostic markers for head and neck cancer

ABSTRACT: The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis biomarkers that may assist in clinical decision making. The protein profiles are strictly associated with immune modulation across datasets, which provided the basis to investigate immune markers associated with metastasis. The proteome of LN metastasis cells quite recapitulates the proteome of primary sites. Conversely, the LN microenvironment proteome highlights candidate markers. By integrating selected markers at peptide, protein, and transcript levels with machine learning models, we indicate a nodal metastasis signature in blood and saliva. In summary, we present the deepest proteome characterization of multiple sampling sites in HNC, providing a promising basis to understand tumoral biology and indicating metastasis-associated biomarkers.

ORGANISM(S): Homo Sapiens

SUBMITTER: Adriana Paes Leme

PROVIDER: PXD027984 | panorama | Tue Nov 22 00:00:00 GMT 2022

REPOSITORIES: PanoramaPublic

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Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer.

Busso-Lopes Ariane F AF Neves Leandro X LX Câmara Guilherme A GA Granato Daniela C DC Pretti Marco Antônio M MAM Heberle Henry H Patroni Fábio M S FMS Sá Jamile J Yokoo Sami S Rivera César C Domingues Romênia R RR Normando Ana Gabriela C AGC De Rossi Tatiane T Mello Barbara P BP Galdino Nayane A L NAL Pauletti Bianca A BA Lacerda Pammela A PA Rodrigues André Afonso N AAN Casarim André Luis M ALM de Lima-Souza Reydson A RA Damas Ingrid I II Mariano Fernanda V FV Gollob Kenneth J KJ Medina Tiago S TS Cervigne Nilva K NK Prado-Ribeiro Ana Carolina AC Brandão Thaís Bianca TB Villa Luisa L LL Uno Miyuki M Boroni Mariana M Kowalski Luiz Paulo LP González-Arriagada Wilfredo Alejandro WA Paes Leme Adriana F AF

Nature communications 20221107 1

The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the biology and potential metastasis biomarkers that may assist in clinical decision-making. Protein profiles are strictly associated with immune modulation across datasets, and this provides the basis fo ...[more]

PMID: 36344512

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Dataset Information

Multisite proteome provides insights into the biology and prognostic markers for head and neck cancer

Publications

Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer.

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