Proteomics

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HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function

ABSTRACT: Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass spectrometry in human regulatory T cells. Interactors, involved in protein transport, mRNA processing, non-coding (ncRNA) transcription and RNA metabolism processes were identified. These data demonstrate that HIC1 is a part of a FOXP3-RUNX1-CBFβ protein complex that regulates Treg signature genes and is indispensable for the suppressive function of FOXP3+ regulatory T cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Robert Moulder  

PROVIDER: PXD038532 | panorama | Mon Oct 16 00:00:00 BST 2023

REPOSITORIES: PanoramaPublic

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HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function.

Andrabi Syed Bilal Ahmad SBA   Batkulwar Kedar K   Bhosale Santosh D SD   Moulder Robert R   Khan Meraj Hasan MH   Buchacher Tanja T   Khan Mohd Moin MM   Arnkil Ilona I   Rasool Omid O   Marson Alexander A   Kalim Ubaid Ullah UU   Lahesmaa Riitta R  

Immunology letters 20231012

Transcriptional repressor, hypermethylated in cancer 1 (HIC1) participates in a range of important biological processes, such as tumor repression, immune suppression, embryonic development and epigenetic gene regulation. Further to these, we previously demonstrated that HIC1 provides a significant contribution to the function and development of regulatory T (Treg) cells. However, the mechanism by which it regulates these processes was not apparent. To address this question, we used affinity-puri  ...[more]

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