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Multiple reaction monitoring based targeted validation of over-expressed proteins of high-grade gliomas

ABSTRACT: High-grade gliomas (HGGs) are extremely aggressive primary brain tumors with high mortality rates. Despite notable advancements in clinical research, HGGs are still characterized by poor prognosis and appalling survival rates. Several global proteomics studies have reported many protein biomarkers however, the transition of these proteins biomarkers from lab to clinic is exceptionally low. In the current study, over-expressed HGG proteins identified from various global proteomics studies were validated in HGG tissue samples to explore their role as potential therapeutic candidates.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ayushi Verma

PROVIDER: PXD043621 | panorama | Thu Aug 01 00:00:00 BST 2024

REPOSITORIES: PanoramaPublic

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Multitarget Potential Drug Candidates for High-Grade Gliomas Identified by Multiple Reaction Monitoring Coupled with <i>In Silico</i> Drug Repurposing.

Verma Ayushi A Patel Rushda R Mahale Atharva A Thorat Rujuta Vijay RV Rath Soumya Lipsa SL Sridhar Epari E Moiyadi Aliasgar A Srivastava Sanjeeva S

Omics : a journal of integrative biology 20240206 2

High-grade gliomas (HGGs) are extremely aggressive primary brain tumors with high mortality rates. Despite notable progress achieved by clinical research and biomarkers emerging from proteomics studies, efficacious drugs and therapeutic targets are limited. This study used targeted proteomics, <i>in silico</i> molecular docking, and simulation-based drug repurposing to identify potential drug candidates for HGGs. Importantly, we performed multiple reaction monitoring (MRM) on differentially expr ...[more]

PMID: 38320249

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