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PSE115_PSM1063_mouse

ABSTRACT: Placentas from naturally-mated crosses of C57Bl/6J mice on embryonic day 17.5 were cut into thick slices. A scalpel blade was used to isolate the blood-red labyrin th tissue from the more poorly vascularized, and hence paler, spongiotrophoblast tissue, and to remove the superficial chorionic vasculature. From each litter, of the colle cted labyrinth tissues were set aside for RNA extraction and microarray analysis and for cellular fractionation and proteomic analysis, as recently described (Kislinger et al., 2006).

OTHER RELATED OMICS DATASETS IN: PRD000474PRJNA109739PRJNA109871

INSTRUMENT(S): LTQ

ORGANISM(S): Mus Musculus

SUBMITTER: brain cox

PROVIDER: PAe001560 | PeptideAtlas | 2009-12-31

REPOSITORIES: PeptideAtlas

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Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology.

Cox Brian B Kotlyar Max M Evangelou Andreas I AI Ignatchenko Vladimir V Ignatchenko Alex A Whiteley Kathie K Jurisica Igor I Adamson S Lee SL Rossant Janet J Kislinger Thomas T

Molecular systems biology 20090616

Placental abnormalities are associated with two of the most common and serious complications of human pregnancy, maternal preeclampsia (PE) and fetal intrauterine growth restriction (IUGR), each disorder affecting approximately 5% of all pregnancies. An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human to mouse. The human and mouse placenta show structural similarities, but there have ...[more]

PMID: 19536202

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