Proteomics

Dataset Information

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MTB_hypoxia

ABSTRACT: LC-MS/MS of cultured Mycobacterium tuberculosis in a hypoxia/reaeration timecourse

OTHER RELATED OMICS DATASETS IN: PXD000045PRJNA186476

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mycobacterium Tuberculosis

SUBMITTER: Galagan et al. 

PROVIDER: PAe004063 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Publications

The Mycobacterium tuberculosis regulatory network and hypoxia.

Galagan James E JE   Minch Kyle K   Peterson Matthew M   Lyubetskaya Anna A   Azizi Elham E   Sweet Linsday L   Gomes Antonio A   Rustad Tige T   Dolganov Gregory G   Glotova Irina I   Abeel Thomas T   Mahwinney Chris C   Kennedy Adam D AD   Allard René R   Brabant William W   Krueger Andrew A   Jaini Suma S   Honda Brent B   Yu Wen-Han WH   Hickey Mark J MJ   Zucker Jeremy J   Garay Christopher C   Weiner Brian B   Sisk Peter P   Stolte Christian C   Winkler Jessica K JK   Van de Peer Yves Y   Iazzetti Paul P   Camacho Diogo D   Dreyfuss Jonathan J   Liu Yang Y   Dorhoi Anca A   Mollenkopf Hans-Joachim HJ   Drogaris Paul P   Lamontagne Julie J   Zhou Yiyong Y   Piquenot Julie J   Park Sang Tae ST   Raman Sahadevan S   Kaufmann Stefan H E SH   Mohney Robert P RP   Chelsky Daniel D   Moody D Branch DB   Sherman David R DR   Schoolnik Gary K GK  

Nature 20130703 7457

We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. Adaptations to hypoxia are thought to have a prominent role in M. tuberculosis pathogenesis. Using ChIP-Seq combined with expression data from the induction of the same factors, we have reconstructed a draft regulatory ne  ...[more]

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