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Hs_VHL

ABSTRACT: Proteomic analysis of signaling network regulation in renal cell carcinomas

REANALYSIS of: PXD000335

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Nagaprashantha LD, Talamantes T, Singhal J, Guo J, Vatsyayan R, Rauniyar N, Awasthi S, Singhal SS, Prokai L

PROVIDER: PAe005018 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.

Nagaprashantha Lokesh Dalasanur LD Talamantes Tatjana T Singhal Jyotsana J Guo Jia J Vatsyayan Rit R Rauniyar Navin N Awasthi Sanjay S Singhal Sharad S SS Prokai Laszlo L

PloS one 20130805 8

<h4>Background</h4>The loss of von Hippel-Lindau (VHL) protein function leads to highly vascular renal tumors characterized by an aggressive course of disease and refractoriness to chemotherapy and radiotherapy. Loss of VHL in renal tumors also differs from tumors of other organs in that the oncogenic cascade is mediated by an increase in the levels of hypoxia-inducible factor-2α (HIF2α) instead of hypoxia-inducible factor-1α (HIF1α).<h4>Methods and principal findings</h4>We used renal carcinoma ...[more]

PMID: 23940778

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