Dataset Information
Mm_cerebella_dimethyl
Ontology highlight
ABSTRACT:
REANALYSIS of: PXD000046
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus
SUBMITTER:
PROVIDER: PAe005208 | PeptideAtlas | 2013-12-31
REPOSITORIES: PeptideAtlas
Publications
Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum.
Molecular & cellular proteomics : MCP 20130211 5
The accumulation of cellular damage, including DNA damage, is hypothesized to contribute to aging-related neurodegenerative changes. DNA excision repair cross-complementing group 1 (Ercc1) knock-out mice represent an accepted model of neuronal aging, showing gradual neurodegenerative changes, including loss of synaptic contacts and cell body shrinkage. Here, we used the Purkinje cell-specific Ercc1 DNA-repair knock-out mouse model to study aging in the mouse cerebellum. We performed an in-depth ...[more]
