Proteomics

Dataset Information

0

Hs-CHPP_LungCancer-Hp-RP-StageTip_H3255


ABSTRACT: Mining Missing Membrane Proteins, Hp-RP StageTips, H3255

REANALYSIS of: PXD002224

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Others

SUBMITTER: Kitata RB, et al. 

PROVIDER: PAe005336 | PeptideAtlas | 2015-12-31

REPOSITORIES: PeptideAtlas

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Publications

Mining Missing Membrane Proteins by High-pH Reverse-Phase StageTip Fractionation and Multiple Reaction Monitoring Mass Spectrometry.

Kitata Reta Birhanu RB   Dimayacyac-Esleta Baby Rorielyn T BR   Choong Wai-Kok WK   Tsai Chia-Feng CF   Lin Tai-Du TD   Tsou Chih-Chiang CC   Weng Shao-Hsing SH   Chen Yi-Ju YJ   Yang Pan-Chyr PC   Arco Susan D SD   Nesvizhskii Alexey I AI   Sung Ting-Yi TY   Chen Yu-Ju YJ  

Journal of proteome research 20150806 9


Despite significant efforts in the past decade toward complete mapping of the human proteome, 3564 proteins (neXtProt, 09-2014) are still "missing proteins". Over one-third of these missing proteins are annotated as membrane proteins, owing to their relatively challenging accessibility with standard shotgun proteomics. Using nonsmall cell lung cancer (NSCLC) as a model study, we aim to mine missing proteins from disease-associated membrane proteome, which may be still largely under-represented.  ...[more]

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