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Apc1638N+/- and p21-/- mouse models of colon cancer

ABSTRACT: DIGE results of mouse models of colon cancer. Tissue harvested from small intestines of Apc1638N+/- and p21-/- mice as per the method developed by Wieser et al. (1973). Spots identified as significant (alpha<0.05) in the comparison of mutant mouse crypts and villi to WT crypts and villi, respectively.

OTHER RELATED OMICS DATASETS IN: PRJNA121709

INSTRUMENT(S): LTQ Orbitrap, instrument model

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Vishal Patel

PROVIDER: PRD000177 | Pride | 2012-05-02

REPOSITORIES: Pride

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	PRIDE_Exp_Complete_Ac_10638.pride.mgf.gz	Mgf
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Publications

Prediction and testing of biological networks underlying intestinal cancer.

Patel Vishal N VN Bebek Gurkan G Mariadason John M JM Wang Donghai D Augenlicht Leonard H LH Chance Mark R MR

PloS one 20100901 9

Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called "driver" genes that provide a growth advantage to the tumor. To identify points of intersection between driver gene pathways, we implemented a network analysis framework using protein interactions to predict likely connections--both precedented and novel--between key driver genes in cancer. We applied the framework to find significant connections between two genes, Apc and Cdkn1a (p21), k ...[more]

PMID: 20824133

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