SCCOR - S100A11 mediates hypoxia-induced mitogenic factor (HIMF)-induced smooth muscle cell migration, vesicular exocytosis, and nuclear activation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, instrument model, LTQ, LTQ XL
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Vascular Smooth Muscle Cell
SUBMITTER: 
Chunling Fan
PROVIDER: PRD000242 | Pride | 2011-05-05
REPOSITORIES: Pride
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S100A11 mediates hypoxia-induced mitogenic factor (HIMF)-induced smooth muscle cell migration, vesicular exocytosis, and nuclear activation.
Fan Chunling C Fu Zongming Z Su Qingning Q Angelini Daniel J DJ Van Eyk Jennifer J Johns Roger A RA
Molecular & cellular proteomics : MCP 20101207 3
Hypoxia-induced mitogenic factor (HIMF) is a newly discovered protein that is up-regulated in murine models of pulmonary arterial hypertension and asthma. Our previous study shows that HIMF is a potent mitogenic, angiogenic, and vasoconstrictive chemokine associated with pulmonary arterial hypertension. Two-dimensional gel electrophoresis was used to investigate downstream molecules in HIMF-induced cell signaling, demonstrating that S100A11, an EF-hand calcium-binding protein, was exclusively al ...[more]
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