Dataset Information

Analysis of the proteome of Shigella dysenteriae serotype I derived from in vitro and in vivo growth conditions

ABSTRACT: Not available

INSTRUMENT(S): instrument model

ORGANISM(S): Shigella Dysenteriae

SUBMITTER: Attila Csordas

PROVIDER: PRD000497 | Pride | 2012-07-26

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	PRIDE_Exp_Complete_Ac_18195.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_18195.pride.mztab.gz	Mztab
	PRIDE_Exp_Complete_Ac_18195.xml.gz	Xml
	PRIDE_Exp_Complete_Ac_18196.pride.mgf.gz	Mgf
	PRIDE_Exp_Complete_Ac_18196.pride.mztab.gz	Mztab

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Publications

The Shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins.

Pieper Rembert R Zhang Quanshun Q Parmar Prashanth P PP Huang Shih-Ting ST Clark David J DJ Alami Hamid H Donohue-Rolfe Arthur A Fleischmann Robert D RD Peterson Scott N SN Tzipori Saul S

Proteomics 20091101 22

Shigella dysenteriae serotype 1 (SD1) causes the most severe form of epidemic bacillary dysentery. We present the first comprehensive proteome analysis of this pathogen, profiling proteins from bacteria cultured in vitro and bacterial isolates from the large bowel of infected gnotobiotic piglets (in vivo). Overall, 1061 distinct gene products were identified. Differential display analysis revealed that SD1 cells switched to an anaerobic energy metabolism in vivo. High in vivo abundances of amino ...[more]

PMID: 19813213

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