Phospho-tyrosine signaling in mouse models of prostate cancer progression
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, instrument model
ORGANISM(S): Mus Musculus (mouse)
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: 
Thomas Graeber
PROVIDER: PRD000615 | Pride | 2012-01-05
REPOSITORIES: Pride
Dataset's files
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Publications
Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.
Drake Justin M JM Graham Nicholas A NA Stoyanova Tanya T Sedghi Amir A Goldstein Andrew S AS Cai Houjian H Smith Daniel A DA Zhang Hong H Komisopoulou Evangelia E Huang Jiaoti J Graeber Thomas G TG Witte Owen N ON
Proceedings of the National Academy of Sciences of the United States of America 20120117 5
Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer. We demonstrate that castration-resistant prostate cancer (CRPC) in men exhibits increased tyrosine phosphorylation, raising the question of whether enhanced tyrosine kinase activity is observed in prostate cancer in the absence of specific tyrosine kinase mutation or DNA amplification. We generated a mouse model of prostate cancer progression using commonly perturbe ...[more]
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