Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sean Cory
PROVIDER: E-GEOD-41718 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ahn Ryuhjin R Sabourin Valerie V Ha Jacqueline R JR Cory Sean S Maric Gordana G Im Young Kyuen YK Hardy W Rod WR Zhao Hong H Park Morag M Hallett Michael M Siegel Peter M PM Pawson Tony T Ursini-Siegel Josie J
Cancer research 20130521 14
ShcA (SHC1) is an adapter protein that possesses an SH2 and a PTB phosphotyrosine-binding motif. ShcA generally uses its PTB domain to engage activated receptor tyrosine kinases (RTK), but there has not been a definitive determination of the role of this domain in tumorigenesis. To address this question, we employed a ShcA mutant (R175Q) that no longer binds phosphotyrosine residues via its PTB domain. Here, we report that transgenic expression of this mutant delays onset of mammary tumors in th ...[more]