Proteomics

Dataset Information

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In-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics


ABSTRACT: In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hippocampus

SUBMITTER: Ute Distler  

LAB HEAD: Ute Distler

PROVIDER: PXD000590 | Pride | 2014-09-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Distler_et_al_peptide_report_fractions.xlsx Xlsx
Distler_et_al_protein_report_fractions.xlsx Xlsx
P2-A1.raw.zip Raw
P2-A2.raw.zip Raw
P2-A3.raw.zip Raw
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Publications

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.

Distler Ute U   Schmeisser Michael J MJ   Pelosi Assunta A   Reim Dominik D   Kuharev Jörg J   Weiczner Roland R   Baumgart Jan J   Boeckers Tobias M TM   Nitsch Robert R   Vogt Johannes J   Tenzer Stefan S  

Proteomics 20141018 21-22


Located at neuronal terminals, the postsynaptic density (PSD) is a highly complex network of cytoskeletal scaffolding and signaling proteins responsible for the transduction and modulation of glutamatergic signaling between neurons. Using ion-mobility enhanced data-independent label-free LC-MS/MS, we established a reference proteome of crude synaptosomes, synaptic junctions, and PSD derived from mouse hippocampus including TOP3-based absolute quantification values for identified proteins. The fi  ...[more]

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