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Identification of Drosophila centromere associated proteins

ABSTRACT: affinity purification-MS analysis of Drosophila centromeric chromatin

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Cell Culture, Early Embryonic Cell

SUBMITTER: Andreas Thomae

LAB HEAD: Axel Imhof

PROVIDER: PXD000758 | Pride | 2014-07-31

REPOSITORIES: Pride

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			Action	DRS
	Barthetal_Proteomics2014-2.zip	Other
	Barthetal_Proteomics2014_mqpar.xml	Xml
	SID1508_H3_3_1.raw	Raw
	SID1508_H3_3_2.raw	Raw
	SID1508_H3_3_3.raw	Raw

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Publications

Identification of novel Drosophila centromere-associated proteins.

Barth Teresa K TK Schade Georg O M GO Schmidt Andreas A Vetter Irene I Wirth Marc M Heun Patrick P Thomae Andreas W AW Imhof Axel A

Proteomics 20140714 19

Centromeres are chromosomal regions crucial for correct chromosome segregation during mitosis and meiosis. They are epigenetically defined by centromeric proteins such as the centromere-specific histone H3-variant centromere protein A (CENP-A). In humans, 16 additional proteins have been described to be constitutively associated with centromeres throughout the cell cycle, known as the constitutive centromere-associated network (CCAN). In contrast, only one additional constitutive centromeric pro ...[more]

PMID: 24841622

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