Dataset Information

BRCA protein subtype - Molecular Portrait of Breast-Cancer-Derived Cell Lines Reveals Poor Similarity with Tumors

ABSTRACT: Shotgun MSMS data of breast tumor intrinsic subtypes

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Fredrik Levander

LAB HEAD: Peter James

PROVIDER: PXD000944 | Pride | 2016-07-08

REPOSITORIES: Pride

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Molecular Portrait of Breast-Cancer-Derived Cell Lines Reveals Poor Similarity with Tumors.

Cifani Paolo P Kirik Ufuk U Waldemarson Sofia S James Peter P

Journal of proteome research 20150622 7

Breast-cancer-derived cell lines are an important sample source for cancer proteomics and can be classified on the basis of transcriptomic analysis into subgroups corresponding to the molecular subtypes observed in mammary tumors. This study describes a tridimensional fractionation method that allows high sequence coverage and proteome-wide estimation of protein expression levels. This workflow has been used to conduct an in-depth quantitative proteomic survey of five breast cancer cell lines ma ...[more]

PMID: 26055192

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