Dataset Information

Effect of TGFbeta-2 on pig gut epithelial cells

ABSTRACT: Proteome and biochemical data were used to describe the anti-inflammatory effect of TGFbeta 2 on pig gut epithelial cells.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Dorte Thomassen

LAB HEAD: Emøke Bendixen

PROVIDER: PXD001465 | Pride | 2016-08-10

REPOSITORIES: Pride

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	sus_TNF.zip	Other

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Publications

Protective effects of transforming growth factor β2 in intestinal epithelial cells by regulation of proteins associated with stress and endotoxin responses.

Nguyen Duc Ninh DN Nguyen Duc Ninh DN Jiang Pingping P Jacobsen Susanne S Sangild Per T PT Bendixen Emøke E Chatterton Dereck E W DE

PloS one 20150210 2

Transforming growth factor (TGF)-β2 is an important anti-inflammatory protein in milk and colostrum. TGF-β2 supplementation appears to reduce gut inflammatory diseases in early life, such as necrotizing enterocolitis (NEC) in young mice. However, the molecular mechanisms by which TGF-β2 protects immature intestinal epithelial cells (IECs) remain to be more clearly elucidated before interventions in infants can be considered. Porcine IECs PsIc1 were treated with TGF-β2 and/or lipopolysaccharide ( ...[more]

PMID: 25668313

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