Dataset Information

Evolution of an outbreak of meningococcal disease among men who have sex with men

ABSTRACT: Neisseria meningitidis (meningococcus) is usually transmitted via respiratory droplets, whereas its close relative, the gonococcus is sexually transmitted. Invasive meningococcal disease due to isolates of serogroup C increased in Europe and the United States among men who have sex with men (MSM). These isolates were also recovered from cases of urethritis suggesting sexual transmission. Genome sequencing of representative strains revealed that isolates from MSM and urethritis cases belonged to a unique clade within clonal complex11. Proteome analysis showed expression of nitrite reductase by these isolates, enabling anaerobic growth as in gonococci. Invasive isolates from MSM, but not urethritis isolates expressed functional human factor H (hfH) binding protein associated with enhanced survival in transgenic mice expressing hfH, a complement regulatory protein. Our data provide a unique example of meningococcal evolution with adaptation to sexual transmissibility, initially associated with low virulence but with subsequent fHbp-associated invasiveness. Implications for vaccination strategies are discussed.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Neisseria Meningitidis Serogroup C / Serotype 2a (strain Atcc 700532 / Dsm 15464 / Fam18)

SUBMITTER: Andreas Otto

LAB HEAD: Andreas Otto

PROVIDER: PXD001498 | Pride | 2016-05-18

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	131210_o3_p4_fb_ml_93_iRT_01.raw	Raw
	131210_o3_p4_fb_ml_93_iRT_02.raw	Raw
	131210_o3_p4_fb_ml_93_iRT_03.raw	Raw
	131210_o3_p4_fb_ml_93_iRT_04.raw	Raw
	131210_o3_p4_fb_ml_93_iRT_05.raw	Raw

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Publications

Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men.

Taha Muhamed-Kheir MK Claus Heike H Lappann Martin M Veyrier Frédéric J FJ Otto Andreas A Becher Dörte D Deghmane Ala-Eddine AE Frosch Matthias M Hellenbrand Wiebke W Hong Eva E Parent du Châtelet Isabelle I Prior Karola K Harmsen Dag D Vogel Ulrich U

PloS one 20160511 5

Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isola ...[more]

PMID: 27167067

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